The fundamental research about he regeneration process of the submandibular gland in vitro.

Research Project

Project/Area Number	16K20621
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Nihon University
Principal Investigator	SHIRATSUCHI Hiroshi 日本大学, 歯学部, 助教 (50710844)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	Salivary gland / Atrophy / Regeneration / in vitro / Aquaporin / TGF-beta / Cytoskeleton / Duct ligation / 唾液腺 / 萎縮 / 再生 / 細胞 / 免疫組織化学 / 細胞骨格 / 再生過程 / 細胞分化
Outline of Final Research Achievements	The aim of this study was to evaluate the cell formation by using in vitro investigation for the salivary gland’s cell. This study enabled us to assess the roles of the various proteins during regeneration of the submandibular gland. Additionally, the correlation between cytoskeleton and TGF-beta was detected in this study. TGF-beta was detected around the duct-like-structures during regeneration process. The result indicated that TGF-beta contributed the rat submandibular regeneration.

Report

(3 results)