Assosciation of osteocytes apoptosis, p53 and CCN2 during mechanical-dependent bone remodeling
| Project/Area Number |
16K20634
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
TAKANO Ikuko 東北大学, 大学病院, 医員 (90770462)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯学 / 機械的刺激 / 骨リモデリング / p53 / CCN2 |
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| Outline of Final Research Achievements |
Bone remodeling, resorption and formation in alveolar bone, occur during orthodontic tooth movement. It was suggested that osteocytes apoptosis associated with bone resorption. Compressive force applied mouse cranial sutures increased the protein expression of CCN2 and p53, and a rate of apoptosis cell. Mechanical stresses induced the expression level of CCN2, p53, apoptosis regulator Bax and Caspase-3 in osteocyte-like cell line MLO-Y4. These findings suggest that compressive force induces the expression of CCN2 and p53 in osteocyte and may enhance apoptosis through activation of caspase signal.
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Report
(3 results)
Research Products
(4 results)
