| Project/Area Number |
16K20635
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
Goto Maki 東北大学, 歯学研究科, 大学院非常勤講師 (20771108)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | iPS細胞 / 歯周組織再生 / 神経堤細胞 / 歯根膜 / 多分化能 / 歯学 / 再生 |
|---|
| Outline of Final Research Achievements |
Periodontal ligament has important role in tooth support, blood supply, sensing, maintenance and regeneration of periodontal tissues. Break down of the periodontal tissues due to periodontitis and other reasons can result in undesirable tooth extraction. In the recent years, it is expected that the regeneration of periodontal tissues using periodontal ligament cell sheet. To achieve this regenerative therapy, large amount of periodontal ligament cells is necessary. In the present study, a novel method to establish the iPS cell-derived periodontal ligament cells has been developed.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、歯周組織の再生に用いるiPS細胞歯根膜細胞樹立に応用可能な前駆細胞である神経堤細胞の分化誘導方法が開発された。これにより、歯周組織再生における細胞ソースの課題を克服し、多くの患者に歯周組織の再生による次世代の治療が提供できることとなり、将来の人類の健康増進に寄与する点で大きな意義を持ち、本研究が与える科学的インパクトは非常に大きい。
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