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Analysis for stimulation of GPR120 for osteoclast formation and orthodontic tooth movement

Research Project

Project/Area Number 16K20637
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionTohoku University

Principal Investigator

Kimura Keisuke  東北大学, 大学病院, 助教 (70712909)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsGPR120 / DHA / 破骨細胞 / 破骨細胞形成 / 矯正学的歯の移動
Outline of Final Research Achievements

PBS, LPS, LPS+DHA, LPS+DHA+AH7614, and DHA were injected subcutaneously on the calvariae of wild-type mice to confirm the LPS-induced osteoclast formation and the inhibitive effect of GPR 120 signaling pathway on LPS-induced osteoclast formation. After supracalvarial injections of reagents, mice were euthanized for preparing paraffin sections of mouse calvaria. TRAP staining was then performed to evaluate osteoclast formation in the suture mesenchyme. In the LPS injection group, many TRAP positive osteoclasts were induced. On the other hand, there was a significant reduction of osteoclast number in the LPS+DHA injection group. In addition, the inhibitive effect of DHA on osteoclast formation was suppressed by selective GPR120 antagonist AH7614, which was shown in the LPS+DHA+AH7614 injection group.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (19 results)

All 2018 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (14 results) (of which Int'l Joint Research: 8 results)

  • [Journal Article] Corrosion resistance and mechanical properties of titanium nitride plating on orthodontic wires2018

    • Author(s)
      Sugisawa, H., Kitaura, H., Ueda, K., Kimura, K., Ishida, M., Ochi, Y., Kishikawa, A., Ogawa, S., Takano-Yamamoto T
    • Journal Title

      Dental Materials Journal

      Volume: 37 Issue: 2 Pages: 286-292

    • DOI

      10.4012/dmj.2016-348

    • NAID

      130006588780

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The glucagon-like peptide-1 receptor agonist exendin-4 inhibits lipopolysaccharide-induced osteoclast formation and bone resorption via inhibition of TNF-α expression in macrophages.2018

    • Author(s)
      Wei-Ren Shen, Keisuke Kimura, Masahiko Ishida, Haruki Sugisawa, Akiko Kishikawa, Kazuhiro Shima, Saika Ogawa, Jiawei Qi, Hideki Kitaura
    • Journal Title

      Journal of Immunology Research

      Volume: 2018 Pages: 5783639-5783639

    • DOI

      10.1155/2018/5783639

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of muramyl dipeptide for lipopolysaccharide-mediated biological activity and osteoclast activity.2018

    • Author(s)
      Kitaura, H., Ishida, M., Kimura, K., Sugisawa, H., Kishikawa A, Shima, K., Ogawa S., Qi J, Kitaura H., Shen WR
    • Journal Title

      Anal. Cell. Pathol.

      Volume: Volume 2018 Pages: 8047610-8047610

    • DOI

      10.1155/2018/8047610

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 歯科矯正用Ni-Tiワイヤーに対する表面コーティングによる耐食性の解析2018

    • Author(s)
      木村桂介,杉澤晴紀,井田裕人,石田匡彦,島和弘,岸川明子,小川紗衣香,北浦英樹
    • Journal Title

      東北矯正歯科学会雑誌

      Volume: 25 Pages: 9-15

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-37 inhibits lipopolysaccharide-induced osteoclast formation and bone resorption in vivo.2016

    • Author(s)
      Saeed J, Kitaura H, Kimura K, Ishida M, Sugisawa H, Ochi Y, Kishikawa A, Takano-Yamamoto T
    • Journal Title

      Immunol Lett.

      Volume: 175 Pages: 8-15

    • DOI

      10.1016/j.imlet.2016.04.004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vivo by glucagon-like peptide-1 receptor agonist.2018

    • Author(s)
      Shen WR, Kimura K, Ishida M, Kishikawa A, Shima K, Ogawa S, Qi J, Ohori F, Noguchi T, Marahleh A, Kitaura H.
    • Organizer
      International Symposium for Multimodal Research and Education in IOHS-Liaison 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparisons with and without retention in orthodontic relapse mouse models.2018

    • Author(s)
      Qi J, Kimura K, Ishida M, Kishikawa A, Shima K, Ogawa S, Shen WR, Ohori F, Noguchi T, Marahleh A, Kitaura H
    • Organizer
      International Symposium for Multimodal Research and Education in IOHS-Liaison 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of IL-18 on mechanical loading-induced osteoclastogenesis and bone resorption.2017

    • Author(s)
      Ochi Y., Kitaura H., Kimura K ., Ishida M., Sugisawa H., Saeed J., Kishikawa A., Qi J., Takano-YAmamoto T.
    • Organizer
      The 2017 Japan-NIH joint Symposium
    • Place of Presentation
      星稜オーディトリアム(宮城県)
    • Year and Date
      2017-02-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of IL-18 on mechanical loading-induced osteoclastogenesis and bone resorption2017

    • Author(s)
      Ochi Y, Kitaura H, Kimura K, Ishida M, Sugisawa H, Saeed J, Kishikawa A, Qi J, Takano-Yamamoto T.
    • Organizer
      The 2017 Japan-NIH joint Symposium.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exendin-4, a GLP-1 receptor agonist, suppresses inflammation-induced osteoclast formation and bone resorption2017

    • Author(s)
      Shen WR, Kimura K, Ishida M, Sugisawa H, Ochi Y, Kishikawa A, Shima K, Ogawa S., Qi J, Kitaura H.
    • Organizer
      The 12th International Workshop on Biomaterials in Interface Science. Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] he effects of diabetic medicine exendin-4 for osteoclast formation and bone resorption.2017

    • Author(s)
      Shen WR, Kimura K, Ishida M, Sugisawa H, Ochi Y, Kishikawa A, Shima K, Ogawa S., Qi J, Kitaura H.
    • Organizer
      The 76th Annual Meeting of the Japanese Orthodontic Society.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脂肪酸受容体GPR120の破骨細胞形成および骨吸収との関連性の検討2017

    • Author(s)
      木村桂介、石田匡彦、島和弘、杉澤晴紀、越智由美子、岸川明子、小川紗衣香、セイ カイ、沈威任、北浦英樹
    • Organizer
      第76回日本矯正歯科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 破骨細胞形成および骨吸収に対する脂肪細胞に発現するケモカインCXCL12の作用の検討2017

    • Author(s)
      島和弘、木村桂介、石田匡彦、杉澤晴紀、越智由美子、岸川明子、小川紗衣香、セイ カイ、沈威任、北浦英樹
    • Organizer
      第76回日本矯正歯科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糖尿病治療薬DPP-4阻害薬による破骨細胞形成および骨吸収への影響について2017

    • Author(s)
      石田匡彦、木村桂介、島和弘、沈威任、北浦英樹
    • Organizer
      第76回日本矯正歯科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TiNコーティングを施した歯科矯正用ワイヤーの摩擦力の検討2017

    • Author(s)
      杉澤晴紀、北浦英樹、上田恭介、木村桂介、石田匡彦、越智由美子、岸川明子、小川紗衣香、山本照子
    • Organizer
      第76回日本矯正歯科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 破骨細胞形成および骨吸収に対するIL-37の作用の検討2016

    • Author(s)
      木村桂介、北浦英樹、石田匡彦、ジャファリ サイード、杉澤晴紀、越智由美子、岸川明子、セイ カイ、山本照子
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      アスティ徳島(徳島県)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 矯正学的歯の移動における破歯細胞形成および歯根吸収へのTNF-αの関与について2016

    • Author(s)
      北浦英樹、木村桂介、石田匡彦、杉澤晴紀、越智由美子、岸川明子、セイ カイ、山本照子
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      アスティ徳島(徳島県)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Oral health-related quality of life and perceptions of jaw dysfunction and maxillofacial asymmetry in orthodontic patients.2016

    • Author(s)
      Kitaura H., Kuroki T., Ishida M., Kimura,. Takano-Yamamoto T.
    • Organizer
      The 23rd General Meeting of the Japanese Association for Dental Science.
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2016-10-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of friction oh titanium nitride plating on orthodontic wires.2016

    • Author(s)
      Sugisawa H., Kitaura H., Ueda K., Kimura K., Ishida M., Ochi Y., Kishikawa A., Ogawa S., Takano-Yamamoto T.
    • Organizer
      The 11th International Workshop on Biomaterials in Interface Science Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2016.
    • Place of Presentation
      バーデン家壮鳳(宮城県)
    • Year and Date
      2016-08-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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