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Analysis of the response mechanism of Runx 2 in tooth movement delay in cleidocranial dysplasia

Research Project

Project/Area Number 16K20638
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionTohoku University

Principal Investigator

BANDO Kanan  東北大学, 大学病院, 医員 (20772198)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords鎖骨頭蓋異形成症 / Runx2 / 歯学
Outline of Final Research Achievements

Runx2 is an essential transcription factor for osteoblast and chondrocyte differentiation necessary for osteogenesis and is known as a causative gene for cleidocranial dysplasia. The Runx2 hetero knockout mouse, which is a model of the cleidocranial dysplasia, may have a decreased mechanical stress response and a decreased promotion of osteoblast cell differentiation. Therefore, in this study, experimental teeth were moved to Runx2 hetero knockout mice and related factors around the teeth were examined. In Runx2 hetero knockout mice, not only the distance of tooth movement but also the reduction of inflammatory cytokines and cell infiltration was observed.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Oral CD103-CD11b+ classical dendritic cells present sublingual antigen and induce Foxp3+ regulatory T cells in draining lymph nodes2017

    • Author(s)
      Tanaka Y, Nagashima H, Bando K, Lu L, Ozaki A, Morita Y, Fukumoto S, Ishii N, Sugawara S
    • Journal Title

      Mucosal Immunol

      Volume: 10 Issue: 1 Pages: 79-90

    • DOI

      10.1038/mi.2016.46

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mouse Model of Hydroquinone Hypersensitivity via Innate and Acquired Immunity and Its Promotion by Combined Reagents2017

    • Author(s)
      Bando K, Tanaka Y, Kuroishi T, Sasaki K, Takano-Yamamoto T, Sugawara S, Endo Y
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 印刷中 Issue: 5 Pages: 1082-1093

    • DOI

      10.1016/j.jid.2016.12.018

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CXCL4 is a novel nickel-binding protein and augments nickel allergy2017

    • Author(s)
      Kuroishi T, Bando K, Tanaka Y, Shishido K, Kinbara M, Ogawa T, Muramoto K, Endo Y, Sugawara S
    • Journal Title

      Clinical and Experimental Allergy

      Volume: 印刷中 Issue: 8 Pages: 1069-1078

    • DOI

      10.1111/cea.12926

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mast cell histamine-mediated transient inflammation following exposure to nickel promotes nickel allergy in mice2016

    • Author(s)
      Kinbara M, Bando K, Shiraishi D, Kuroishi T, Nagai Y, Ohtsu H, Takano-Yamamoto T, Sugawara S, Endo Y
    • Journal Title

      Exp Dermatol.

      Volume: 印刷中 Issue: 6 Pages: 466-71

    • DOI

      10.1111/exd.12985

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

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Published: 2016-04-21   Modified: 2019-03-29  

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