| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Runx2 is an essential transcription factor for osteoblast and chondrocyte differentiation necessary for osteogenesis and is known as a causative gene for cleidocranial dysplasia. The Runx2 hetero knockout mouse, which is a model of the cleidocranial dysplasia, may have a decreased mechanical stress response and a decreased promotion of osteoblast cell differentiation. Therefore, in this study, experimental teeth were moved to Runx2 hetero knockout mice and related factors around the teeth were examined. In Runx2 hetero knockout mice, not only the distance of tooth movement but also the reduction of inflammatory cytokines and cell infiltration was observed.
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