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Relationship between physical activity and mandibular growth: morphometric analysis of human facial skeleton and experiment using a mouse voluntary climbing exercise model

Research Project

Project/Area Number 16K20639
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Shimizu Yasuhiro  東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (60631968)

Research Collaborator AOKI kazuhiro  
KAIFU yousuke  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords身体運動 / 咀嚼刺激 / 顎骨成長 / 顎骨形態 / 咬筋 / 顎顔面形態 / 咀嚼運動 / 身体運動刺激 / マイクロCT
Outline of Final Research Achievements

We have shown that physical activity during growth period may affect morphological changes in the mandible using by a mouse voluntary climbing exercise model.
In human specimens, morphometric analysis between high ranked warrior and townspeople in the Edo period and between races in modern women (Japanese and Spanish) suggested that differences in masticatory muscle movement may affect morphological changes in the mandible.

Academic Significance and Societal Importance of the Research Achievements

研究成果として成長期における生活習慣が顎骨形態に影響を与える可能性が示唆された。
歯科領域において成長期に顎骨の成長をコントロールすることは正常咬合を獲得する上で重要であるため、顎骨成長に与える要因を明らかにすることは臨床的意義が高い。顎骨の成長を鑑みた成長期における生活習慣の重要性が明らかとなれば、将来の応用展開に向けた学術基盤を構築することとなり、社会的意義は大きいと考える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (4 results)

  • [Journal Article] Comparison of cephalometric variables between adult Spanish and Japanese women with class I malocclusion2018

    • Author(s)
      Shimizu Yasuhiro、Arx JoseDuran Von、Ustrell JosepMaria、Ono Takashi
    • Journal Title

      journal of orthodontic science

      Volume: 7 Issue: 1 Pages: 19-19

    • DOI

      10.4103/jos.jos_66_18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Occlusal disharmony-induced stress causes osteopenia of the lumbar vertebrae and long bones in mice2018

    • Author(s)
      Shimizu Yasuhiro、Khan Masud、Kato Genki、Aoki Kazuhiro、Ono Takashi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 173-173

    • DOI

      10.1038/s41598-017-18037-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional structural analysis of the morphological condition of the alveolar bone before and after orthodontic treatment2017

    • Author(s)
      Shimizu Yasuhiro、Ono Takashi
    • Journal Title

      The Korean Journal of Orthodontics

      Volume: 47 Issue: 6 Pages: 394-394

    • DOI

      10.4041/kjod.2017.47.6.394

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ultrasound microbubble-mediated transfection of NF-κB decoy oligodeoxynucleotide into gingival tissues inhibits periodontitis in rats in vivo2017

    • Author(s)
      Yamaguchi Hiroyuki、Ishida Yuji、Hosomichi Jun、Suzuki Jun-ichi、Hatano Kasumi、Usumi-Fujita Risa、Shimizu Yasuhiro、Kaneko Sawa、Ono Takashi
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 11 Pages: e0186264-e0186264

    • DOI

      10.1371/journal.pone.0186264

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low-intensity pulsed ultrasound reduces periodontal atrophy in occlusal hypofunctional teeth.2017

    • Author(s)
      Kasahara Y, Usumi-Fujita R, Hosomichi J, Kaneko S, Ishida Y, Shibutani N, Shimizu Y, Okito A, Oishi S, Kuma Y, Yamaguchi H, Ono T.
    • Journal Title

      The ANGLE ORTHODONTIST

      Volume: 印刷中 Issue: 5 Pages: 709-716

    • DOI

      10.2319/121216-893.1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 成長期の運動刺激が顔かたちに与える影響 - マウス運動刺激モデルを用いた下顎骨形態解析2018

    • Author(s)
      清水康広、青木和広、小野卓史
    • Organizer
      第72回日本人類学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 現代スペイン人および日本人女性に対する頭部X線規格写真を用いた形態学的比較検討2017

    • Author(s)
      清水康広、小野卓史
    • Organizer
      第71回日本人類学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 成長期における間欠的低酸素曝露はラット鼻腔気道の炎症亢進を介した形態変化をもたらす2016

    • Author(s)
      隈陽一郎、臼見莉沙、細道純、大石修史、山口博之、沖藤明日香、清水康広、渋谷直樹、石田雄之、金香佐和、鈴木淳一、吉田謙一、小野卓史
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Research-status Report
  • [Presentation] LIPUS照射は咬合刺激低下歯の歯周組織を回復する2016

    • Author(s)
      笠原由紀、臼見莉沙、隈陽一郎、大石修史、沖藤明日香、清水康広、渋谷直樹、石田雄之、金香佐和、細道純、小野卓史
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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