Establishment of advanced orthodontic treatment using laser having metabolic activity of periodontal tissue

• Project/Area Number: 16K20644
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Tsuka Yuji 広島大学, 病院(歯), 歯科診療医 (50737682)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: laser / tooth movement / Bone metabolism / corticotmy / 細胞増殖 / レーザー / 歯の移動 / 歯学 / シグナル伝達 / 再生医学 / 細胞・組織

Outline of Final Research Achievements

This experiment demonstrated that the use of semiconductor laser irradiation during orthodontic treatment promotes tooth movement at the cellular level and animal experimental level. Although it is at the cell level and at the animal experimental level, it was found that the optimal or proper dose can be elucidated, and the tissue irradiation is enhanced by laser irradiation. If this develops further, it is possible to carry out safer orthodontic treatment while preventing or suppressing the destruction of the periodontal tissue during orthodontic treatment.

Research Products

• [Journal Article] Effects of high-frequency near-infrared diode laser irradiation on the proliferation and migration of mouse calvarial osteoblasts. (2018)
  • Author(s): Kunimatsu R, Gunji H, Tsuka Y, Yoshimi Y, Awada T, Sumi K, Nakajima K, Kimura A, Hiraki T, Abe T, Naoto H, Yanoshita M, Tanimoto K.
  • Journal Title: Lasers Med Sci. Volume: 印刷中 Issue: 5 Pages: 959-966
  • DOI: 10.1007/s10103-017-2426-0
  • Peer Reviewed / Open Access
• [Journal Article] Effect of high-frequency near-infrared diode laser irradiation on periodontal tissues during experimental tooth movement in rats. (2018)
  • Author(s): Gunji H, Kunimatsu R, Tsuka Y, Yoshimi Y, Sumi K, Awada T, Nakajima K, Kimura A, Hiraki T, Hirose N, Yanoshita M, Tanimoto K
  • Journal Title: Lasers Surg Med. Volume: 印刷中 Issue: 7 Pages: 772-780
  • DOI: 10.1002/lsm.22797
  • Peer Reviewed / Open Access
• [Journal Article] Molecular biological and histological effects of Er:YAG laser irradiation on tooth movement. (2018)
  • Author(s): Tsuka Y, Kunimatsu R, Gunji H, Nakajima K, Hiraki T, Nakatani A, Tanimoto K
  • Journal Title: J Oral Sci Volume: -
  • NAID: 130007626610
  • Peer Reviewed
• [Journal Article] Effects of Neodymium-Doped Yttrium Aluminium Garnet (Nd:YAG) Laser Irradiation on Bone Metabolism During Tooth Movement (2016)
  • Author(s): Yuji Tsuka*, Tadashi Fujita, Maya Shirakura, Ryo Kunimatsu, Shao-Ching Su, Eri Fujii, Kotaro Tanimoto
  • Journal Title: Journal of lasers in Medical Sciences Volume: Winter 7(1) Issue: 1 Pages: 40-44
  • DOI: 10.15171/jlms.2016.09
  • Peer Reviewed / Open Access
• [Presentation] Effect of Nd:YAG laser irradiation on the osteoblasts (2016)
  • Author(s): Tsuka Y., Kunimatsu R., Gunji H., Nakajima K., Tanimoto K.
  • Organizer: The 49 Korean Association Orthodontists
  • Place of Presentation: Seoul Korea
  • Year and Date: 2016-11-04
  • Int'l Joint Research