| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this study, we analyzed the molecular mechanism of IGFBP6 promoting the differentiation of periodontal ligament cells (HPDL) from both aspects of IGF-dependent and IGF-independent pathway. First, IGF2 was added at the time of differentiation induction of HPDL, but no effect was observed. In addition, it was revealed that the concentration of IGF2 secreted by ADMPC is lower than the concentration of IGFBP6. It was also revealed that ADMPC express not only IGFBP6 but also various extracellular matrix proteins. These results suggested that IGFBP6 secreted by ADMPC acts cooperatively with humoral factors other than IGF, thereby activating periodontal ligament cells and inducing tissue regeneration.
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