The role of IGFBP6 in periodontal tissue regeneration by adipose tissue-derived multi-lineage progenitor cell transplantation
| Project/Area Number |
16K20669
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Osaka University |
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Principal Investigator |
Sawada Keigo 大阪大学, 歯学部附属病院, 医員 (70733054)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯学 / 再生医学 / 歯周再生医学 |
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| Outline of Final Research Achievements |
In this study, we analyzed the molecular mechanism of IGFBP6 promoting the differentiation of periodontal ligament cells (HPDL) from both aspects of IGF-dependent and IGF-independent pathway. First, IGF2 was added at the time of differentiation induction of HPDL, but no effect was observed. In addition, it was revealed that the concentration of IGF2 secreted by ADMPC is lower than the concentration of IGFBP6. It was also revealed that ADMPC express not only IGFBP6 but also various extracellular matrix proteins. These results suggested that IGFBP6 secreted by ADMPC acts cooperatively with humoral factors other than IGF, thereby activating periodontal ligament cells and inducing tissue regeneration.
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Report
(3 results)
Research Products
(14 results)
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[Presentation] Periodontal tissue regeneration by adipose tissue-derived multi-lineage progenitor cell transplantation2016
Author(s)
M Takedachi, K Sawada, T Iwayama, S Yamamoto, C Morimoto, A Hirai, C Man Lee, H Okura, A Matsuyama, Y Sano, M Kitamura, S Murakami
Organizer
The 102nd Annual Meeting of the American Academy of Periodontology
Place of Presentation
San Diego、California (USA)
Year and Date
2016-09-10
Related Report
Int'l Joint Research
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[Presentation] The mechanism of periodontal tissue regeneration by transplantation of adipose tissue-derived multi-lineage progenitor cells2016
Author(s)
Keigo Sawada, Masahide Takedachi, Tomoaki Iwayama, Satomi Yamamoto, Chiaki Morimoto, Asae Hirai, Chun Man Lee, Hanayuki Okura, Akifumi Matsuyama, Yuko Sano, Masahiro Kitamura, Shinya Murakami
Organizer
ISSCR 2016
Place of Presentation
San Francisco, California (USA)
Year and Date
2016-06-22
Related Report
Int'l Joint Research
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