Functional analysis of HMGB1 as an inflammatory mediator in periodontitis
| Project/Area Number |
16K20670
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
AOYAGI Hiroaki 岡山大学, 大学病院, 医員 (10814501)
IDEGUCHI Hidetaka 岡山大学, 医歯薬学総合研究科, 助教 (80779421)
KOCHI Shinsuke 岡山大学, 医歯薬学総合研究科, 助教 (70803138)
YAMAMOTO Tadashi 岡山大学, 大学病院, 講師 (50432662)
TAKASHIBA Shogo 岡山大学, 医歯薬学総合研究科, 教授 (50226768)
WAKE Hidenori 岡山大学, 医歯薬学総合研究科, 講師 (60570520)
NISHIBORI Masahiro 岡山大学, 医歯薬学総合研究科, 教授 (50135943)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症 / 歯周病 / サイトカイン / HMGB1 / マクロファージ / 歯肉上皮細胞 / 好中球 / 歯周炎 / 炎症性サイトカイン / 抗体療法 / 歯学 / 免疫学 / 遺伝子 |
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| Outline of Final Research Achievements |
High mobility group box 1 (HMGB 1) is a DNA binding protein, but it plays as an inflammatory mediator when it is secreted extracellularly due to tissue damage or necrosis. The detailed mechanism of how HMGB1 affects the progress of periodontitis has not been elucidated. As a result of this study, it was revealed that HMGB1 was produced from gingival epithelial cells, macrophage-like cells by inflammatory stimulation. In addition, by administering anti-HMGB 1 antibody to periodontitis model mice, inflammation due to periodontitis is suppressed. As a result, migration of neutrophils, production of IL-1βwere suppressed and the bone resorption by periodontitis was suppressed.
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Report
(3 results)
Research Products
(8 results)
