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Impact of insulin on experimental periodontitis in diabetic rats

Research Project

Project/Area Number 16K20683
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Periodontology
Research InstitutionAichi Gakuin University

Principal Investigator

Nishikawa Toru  愛知学院大学, 歯学部, 非常勤講師 (90771262)

Research Collaborator Kikuchi Takeshi  愛知学院大学, 歯学部, 准教授
Miyajima Shin-ichi  愛知学院大学, 歯学部, 非常勤講師
Adachi Kei  愛知学院大学, 歯学部, 非常勤助教
Suzuki Yuki  愛知学院大学, 歯学部, 非常勤助教
Matsubara Tatsuaki  愛知学院大学, 歯学部, 教授
Naruse Keiko  愛知学院大学, 歯学部, 准教授
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords歯周病 / 糖尿病 / インスリン / iNOS / TNF-α / ニトロチロシン / ニトロ化反応 / 歯学 / 内科
Outline of Final Research Achievements

In this study, we have investigated whether administration of insulin improves periodontitis without any other treatments for periodontitis under the diabetic condition using the ligature-induced experimental periodontitis model.
The treatment of insulin significantly ameliorated diabetic periodontitis without the local treatment of periodontitis in the STZ-induced diabetic rats, which strongly supports that the adequate treatment of insulin are necessary for the therapy of periodontitis in type 1 diabetic patients. Anti-inflammatory effect of insulin suggests the beyond lowering glucose lowering in the treatment of diabetic periodontitis.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Anti-inflammatory role of glucose-dependent insulinotropic polypeptide in periodontitis2016

    • Author(s)
      Suzuki Y, Nakamura N, Miyabe M, Nishikawa T, Miyajima S, Adachi K, Mizutani M, Kikuchi T, Miyazawa K, Goto S, Tsukiyama K, Yamada Y, Ohno N, Noguchi T, Mitani A, Matsubara T, Naruse K
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 印刷中 Issue: 4 Pages: 497-505

    • DOI

      10.1111/jdi.12450

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 糖尿病誘導ラットにおけるインスリン投与が実験的歯周炎に及ぼす影響2017

    • Author(s)
      西川徹
    • Organizer
      日本歯科保存学会2017年度春季学術大会(第146回)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 慢性歯周炎患者の下顎大臼歯部に骨移植術を行った一症例2016

    • Author(s)
      西川徹、菊池毅、真岡淳之、三谷章雄
    • Organizer
      第11回 日本歯周病学会中部地区大学・日本臨床歯周病学会中部支部合同研究会
    • Place of Presentation
      朝日大学(岐阜県、瑞穂市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] GIPによる歯周炎抑制経路の検討2016

    • Author(s)
      鈴木佑基、成瀬桂子、中村信久、宮部愛、西川徹、宮島真一、菊池毅、松原達昭、三谷章雄
    • Organizer
      第11回 日本歯周病学会中部地区大学・日本臨床歯周病学会中部支部合同研究会
    • Place of Presentation
      朝日大学(岐阜県、瑞穂市)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] GIPによる歯周炎抑制作用についての検討2016

    • Author(s)
      鈴木佑基、成瀬桂子、小林泰子、中村信久、宮部愛、西川徹、宮島真一、足立圭、水谷誠、菊池毅、宮澤健、後藤滋巳、月山克史、山田祐一郎、大野紀和、野口俊英、三谷章雄、松原達昭
    • Organizer
      第59回日本糖尿病学会
    • Place of Presentation
      京都(国立京都国際会館など)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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