Impact of insulin on experimental periodontitis in diabetic rats
| Project/Area Number |
16K20683
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
Nishikawa Toru 愛知学院大学, 歯学部, 非常勤講師 (90771262)
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| Research Collaborator |
Kikuchi Takeshi 愛知学院大学, 歯学部, 准教授
Miyajima Shin-ichi 愛知学院大学, 歯学部, 非常勤講師
Adachi Kei 愛知学院大学, 歯学部, 非常勤助教
Suzuki Yuki 愛知学院大学, 歯学部, 非常勤助教
Matsubara Tatsuaki 愛知学院大学, 歯学部, 教授
Naruse Keiko 愛知学院大学, 歯学部, 准教授
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯周病 / 糖尿病 / インスリン / iNOS / TNF-α / ニトロチロシン / ニトロ化反応 / 歯学 / 内科 |
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| Outline of Final Research Achievements |
In this study, we have investigated whether administration of insulin improves periodontitis without any other treatments for periodontitis under the diabetic condition using the ligature-induced experimental periodontitis model.
The treatment of insulin significantly ameliorated diabetic periodontitis without the local treatment of periodontitis in the STZ-induced diabetic rats, which strongly supports that the adequate treatment of insulin are necessary for the therapy of periodontitis in type 1 diabetic patients. Anti-inflammatory effect of insulin suggests the beyond lowering glucose lowering in the treatment of diabetic periodontitis.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Anti-inflammatory role of glucose-dependent insulinotropic polypeptide in periodontitis2016
Author(s)
Suzuki Y, Nakamura N, Miyabe M, Nishikawa T, Miyajima S, Adachi K, Mizutani M, Kikuchi T, Miyazawa K, Goto S, Tsukiyama K, Yamada Y, Ohno N, Noguchi T, Mitani A, Matsubara T, Naruse K
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Journal Title
Journal of Diabetes Investigation
Volume: 印刷中
Issue: 4
Pages: 497-505
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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