| Project/Area Number |
16K20683
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
Nishikawa Toru 愛知学院大学, 歯学部, 非常勤講師 (90771262)
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| Research Collaborator |
Kikuchi Takeshi 愛知学院大学, 歯学部, 准教授
Miyajima Shin-ichi 愛知学院大学, 歯学部, 非常勤講師
Adachi Kei 愛知学院大学, 歯学部, 非常勤助教
Suzuki Yuki 愛知学院大学, 歯学部, 非常勤助教
Matsubara Tatsuaki 愛知学院大学, 歯学部, 教授
Naruse Keiko 愛知学院大学, 歯学部, 准教授
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯周病 / 糖尿病 / インスリン / iNOS / TNF-α / ニトロチロシン / ニトロ化反応 / 歯学 / 内科 |
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| Outline of Final Research Achievements |
In this study, we have investigated whether administration of insulin improves periodontitis without any other treatments for periodontitis under the diabetic condition using the ligature-induced experimental periodontitis model.
The treatment of insulin significantly ameliorated diabetic periodontitis without the local treatment of periodontitis in the STZ-induced diabetic rats, which strongly supports that the adequate treatment of insulin are necessary for the therapy of periodontitis in type 1 diabetic patients. Anti-inflammatory effect of insulin suggests the beyond lowering glucose lowering in the treatment of diabetic periodontitis.
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