Investigation of the effect of the estrogen in angiogenesis for promoting cutaneous wound healing in diabetic ulcer
Project/Area Number |
16K20712
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Fundamental nursing
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Research Institution | Kanazawa University |
Principal Investigator |
Mukai Kanae 金沢大学, 保健学系, 助教 (30755335)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | エストロゲン / 皮膚創傷治癒 / 糖尿病 / 創傷治癒 / 細胞・組織 |
Outline of Final Research Achievements |
Diabetic ulcer is one of the most serious complications. The treatment of diabetic ulcers is difficult; therefore, the development of an effective local wound treatment is desired. In this study, we investigated the effect of estrogen on cutaneous wound healing in diabetes mellitus mice model. The db/db mice were used as a model for type 2 diabetes, and wound healing process and several immunohistochemical staining methods were performed. It was observed that estrogen promoted cutaneous wound healing in type 2 diabetes mice model by increasing Ym1 positive cells and promoting re-epithelialization and angiogenesis.
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Academic Significance and Societal Importance of the Research Achievements |
糖尿病性潰瘍の治療は難渋することが多いのが現状であり、効果的な局所創傷治療の開発が切望されている。本研究課題では皮膚創傷治癒に効果的に作用する女性ホルモンのエストロゲンに着目し、糖尿病性潰瘍皮膚創傷治癒への効果を検証した。その結果、2型糖尿病マウスへのエストロゲン投与がYm1陽性細胞数を増加させ、上皮形成や脈管形成を促進し、皮膚創傷治癒に促進的に作用することが明らかとなった。本研究成果は糖尿病性潰瘍治療へ向けた、新たな方向性を提言できる可能性が考えられる。
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Report
(3 results)
Research Products
(42 results)
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[Journal Article] Effectiveness of changing the application of Japanese honey to a hydrocolloid dressing in between the inflammatory and proliferative phases on cutaneous wound healing in male mice2017
Author(s)
Kanae Mukai, Emi Komatsu, Misa Yamanishi, Misako Hutakuchi, Kayo Kanzaka, Yuka Uno, Shizuka Yamazaki, Shizuka Kato, Tomomi Yamamoto, Mayumi Hattori, Yukari Nakajima, Tamae Urai, Kimi Asano, Naoko Murakado, Mayumi Okuwa, Toshio Nakatani
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Journal Title
WOUNDS
Volume: 29
Pages: 1-9
Related Report
Peer Reviewed
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[Presentation] Effects of honeydew honey on wound healing2016
Author(s)
Yukari Nakajima, Kanae Mukai, Tamae Urai, Kimi Asano, Megumi Ohta, Ikuko Kato, Azusa Kawaguchi, Yui Kinoshita, Yuri Kumagai, Ayaka Sakashita, Takuto Sawazaki, Asuka Yamazaki, Toshio Nakatani
Organizer
WUWHS2016
Place of Presentation
バッソ要塞(イタリア フィレンツェ)
Year and Date
2016-09-25
Related Report
Int'l Joint Research
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