| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Diabetic ulcer is one of the most serious complications. The treatment of diabetic ulcers is difficult; therefore, the development of an effective local wound treatment is desired. In this study, we investigated the effect of estrogen on cutaneous wound healing in diabetes mellitus mice model. The db/db mice were used as a model for type 2 diabetes, and wound healing process and several immunohistochemical staining methods were performed. It was observed that estrogen promoted cutaneous wound healing in type 2 diabetes mice model by increasing Ym1 positive cells and promoting re-epithelialization and angiogenesis.
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