| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Obesity is recognized as one of the risk factor on dermatologic diseases.However, the impact of obesity on the skin has received minimal attention despite its suspected critical role.
We determined whether elastic fibers decrease in the skin of obese.The abundance of elastic fibers of skin was reduced in obese mice. Fibrillin-1 mRNA levels in obese mice were significantly suppressed compared with those in lean mice, whereas neprilysin mRNA levels and immunohistochemical expression in obese mice were significantly increased, as compared with those in lean mice.The reduction in elastic fibers was suggested that initially caused by increased neprilysin and decreased fibrillin-1 expression.
In addition,I investigated skin elastic fiber among Japanese women of varying body mass index (BMI). The abundance of elastic fibers of skin was negatively correlated with BMI.
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