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Development of surface-enhanced Raman scattering substrates with high sensitivity using active gap control system

Research Project

Project/Area Number 16K20870
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nanomaterials chemistry
Device related chemistry
Research InstitutionHokkaido University

Principal Investigator

Mitomo Hideyuki  北海道大学, 電子科学研究所, 准教授 (50564952)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords金ナノ構造 / 動的構造制御 / 表面プラズモン / ゲル / プラズモン / 金ナノ粒子 / 表面増強ラマン散乱 / 高感度検出 / 分子検出
Outline of Final Research Achievements

In this study, to fabricate a biosensing substrate with ultra high sensitivity, active control of gold nanostructures on hydrogels was studied.
1. The method, by which gold nanostructures prepared on the silicon substrates was transferred onto the hydrogel, was improved. As a result, gold nanostructures were efficiently transferred onto the hydrogel and the transfer onto the thermoresponsive hydrogel was also succeeded.
2. Active gap control of gold nanostructures on the hydrogel was evaluated by the electron microscopy. It was observed that the gap distances were homogenously changed in a nanometer-scale. This result supports precise control of the gaps is possible using volume change of the hydrogels.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (28 results)

All 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (16 results) (of which Int'l Joint Research: 8 results,  Invited: 3 results) Book (1 results) Remarks (2 results)

  • [Int'l Joint Research] ニューカッスル大(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ニューカッスル大学(英国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Two-Step Assembly of Thermoresponsive Gold Nanorods Coated with a Single Kind of Ligand2018

    • Author(s)
      Iida Ryo、Mitomo Hideyuki、Niikura Kenichi、Matsuo Yasutaka、Ijiro Kuniharu
    • Journal Title

      Small

      Volume: 14 Issue: 14 Pages: 1704230-1704230

    • DOI

      10.1002/smll.201704230

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA Brush-Directed Vertical Alignment of Extensive Gold Nanorod Arrays with Controlled Density2017

    • Author(s)
      Nakamura Satoshi、Mitomo Hideyuki、Aizawa Miho、Tani Takeharu、Matsuo Yasutaka、Niikura Kenichi、Pike Andrew、Naya Masayuki、Shishido Atsushi、Ijiro Kuniharu
    • Journal Title

      ACS Omega

      Volume: 2 Issue: 5 Pages: 2208-2213

    • DOI

      10.1021/acsomega.7b00303

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] pH-Responsive Coassembly of Oligo(ethylene glycol)-Coated Gold Nanoparticles with External Anionic Polymers via Hydrogen Bonding2017

    • Author(s)
      Torii Yu、Sugimura Naotoshi、Mitomo Hideyuki、Niikura Kenichi、Ijiro Kuniharu
    • Journal Title

      Langmuir

      Volume: 33 Issue: 22 Pages: 5537-5544

    • DOI

      10.1021/acs.langmuir.7b01084

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metal nanoarchitecture fabrication using DNA as a biotemplate2017

    • Author(s)
      Ijiro Kuniharu、Mitomo Hideyuki
    • Journal Title

      Polymer Journal

      Volume: 49 Issue: 12 Pages: 815-824

    • DOI

      10.1038/pj.2017.63

    • NAID

      40021391999

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation of Plasmonic Vesicles through the Self-assembly of Sugar-terminated Fluorinated Oligo(ethylene glycol) Ligand-tethered Gold Nanoparticles2017

    • Author(s)
      J. Wei, K. Niikura, H. Mitomo, Y. Mastuo, K. Ijiro
    • Journal Title

      Journal of Nanoscience and Nanotechnology

      Volume: 未定

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preparation and characterization of double-stranded DNA brushes via surface-initiated enzymatic polymerization2017

    • Author(s)
      H. Mitomo, S. Nakamura, Y. Suzuki, Y. Matsuo, K. Niikura, K. Ijiro
    • Journal Title

      Journal of Nanoscience and Nanotechnology

      Volume: 未定

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reverse Size Dependences of the Cellular Uptake of Triangular and Spherical Gold Nanoparticles2016

    • Author(s)
      K. Nambara, K. Niikura, H. Mitomo, T. Ninomiya, C. Takeuchi, J. Wei, Y. Matsuo, K. Ijiro
    • Journal Title

      Langmuir

      Volume: 32 Issue: 47 Pages: 12559-12567

    • DOI

      10.1021/acs.langmuir.6b02064

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 一種類の表面リガンド分子で修飾した金ナノロッドが示す温度応答型2段階集合2018

    • Author(s)
      飯田良、三友秀之、新倉謙一、居城邦治
    • Organizer
      日本化学会第98回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] オリゴエチレングリコール誘導体で被覆された温度応答性金ナノ粒子:粒径及び形状の効果2017

    • Author(s)
      飯田良、新倉謙一、三友秀之、居城邦治
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県横浜市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] ゲル表面に配置した金微細構造のギャップ制御と電子顕微鏡による直接観察2017

    • Author(s)
      濵島 暁、三友 秀之、松尾 保孝、新倉 謙一、居城 邦治
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県横浜市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Polymer-Supported Self-assembly of Gold Nanoparticles2017

    • Author(s)
      Hideyuki Mitomo, Satoshi Nakamura,Yasutaka Matsuo, Kenichi Niikura, and Kuniharu Ijiro,
    • Organizer
      The 28th International Conference on Molecular Electronics and Devices (IC ME&D 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] DNA brush-assisted vertical alignment of gold nanorods and those chiral plasmonics2017

    • Author(s)
      Hideyuki Mitomo, Satoshi Nakamura, Andrew Pike, Yasutaka Matsuo, Kuniharu Ijiro,
    • Organizer
      SPIE. optics+photonics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Vertical alignment of gold nanorods through the immobilization onto DNA grafted substrates2017

    • Author(s)
      Hideyuki Mitomo, Satoshi Nakamura, Miho Aizawa, Yasutaka Matsuo, Kenichi Niikura, Atsushi Shishido, and Kuniharu Ijiro
    • Organizer
      10th International Symposium on Nature-Inspired Technology (ISNIT2017),
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Vertically aligned gold nanorod array with a flexible structure immobilized onto DNA-grafted substrates2017

    • Author(s)
      Hideyuki Mitomo, Satoshi Nakamura, Miho Aizawa, Yasutaka Matsuo, Kenichi Niikura, Takeharu Tani, Masayuki Naya, Atsushi Shishido, and Kuniharu Ijiro
    • Organizer
      The 11th Asia-Pacific Conference on Near-Field Optics (APNFO11)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カチオン性金ナノロッドの相互作用を利用した配向制御2017

    • Author(s)
      三友 秀之、中村 聡、松尾 保孝、新倉 謙一、居城 邦治
    • Organizer
      第68回コロイド界面化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] DNAとの静電相互作用を利用したカチオン性金ナノロッド配向集積化2017

    • Author(s)
      三友 秀之、中村 聡、相沢 美帆、松尾 保孝、新倉 謙一、宍戸 厚、居城 邦治
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ハイドロゲル表面に作製した金ナノ構造体のギャップ距離変化の評価2017

    • Author(s)
      濱島暁、三友秀之、松尾保孝、新倉謙一、居城邦治
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Metal Pattern formations templated on DNA brushes2016

    • Author(s)
      H. Mitomo, S. Nakamura, Y. Suzuki, Y. Matsuo, K. Niikura, K. Ijiro
    • Organizer
      Asian Conference on Nanoscience and Nanotechnology (AsiaNANO 2016)
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 曲率依存性を示す金ナノ粒子の温度応答性自己集合化2016

    • Author(s)
      飯田 良、三友 秀之、 新倉 謙一、居城 邦治
    • Organizer
      第65回高分子討論会
    • Place of Presentation
      神奈川大学(神奈川県横浜市)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Tuning of anisotropic optical properties of gold nanorods by immobilization on DNA brush substrates2016

    • Author(s)
      H. MITOMO, S. NAKAMURA, Y. MATSUO, K. NIIKURA, K. IJIRO
    • Organizer
      KJF International Conference on Organic Materials for Electronics and Photonics 2016 (KJF-ICOMEP 2016)
    • Place of Presentation
      アクロス福岡(福岡県福岡市)
    • Year and Date
      2016-09-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Self-assembled alignment of nanorod by using DNA brush2016

    • Author(s)
      K. Ijiro, S. Nakamura, H. Mitomo, A. Pike, Y. Matsuo, K. Niikura
    • Organizer
      SPIE Optics + Photonics
    • Place of Presentation
      California (USA)
    • Year and Date
      2016-08-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamic change of self-assembled metal nanoparticle film providing a highly functional application2016

    • Author(s)
      H. Mitomo, K. Horie, Y. Matso, K. Niikura, K. Ijiro
    • Organizer
      16th International Conference on Organized Molecular Films (ICOMF16) - LB16
    • Place of Presentation
      Helsinki (Finland)
    • Year and Date
      2016-07-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Immobilization of AuNR aligned by DNA brush substrate2016

    • Author(s)
      S. Nakamura, H. Mitomo, Y. Matsuo, K. Niikura, K. Ijiro
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2016-05-25
    • Related Report
      2016 Research-status Report
  • [Book] Stimuli-responsive structure control of gold nanoparticle assembly2017

    • Author(s)
      Hideyuki MITOMO, Kenichi NIIKURA, Kuniharu IJIRO,
    • Total Pages
      313
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report
  • [Remarks] 北海道大学電子科学研究所生体分子デバイス研究分野のホームページ

    • URL

      https://chem.es.hokudai.ac.jp

    • Related Report
      2017 Annual Research Report
  • [Remarks] 生体分子デバイス研究分野(HP)

    • URL

      http://chem.es.hokudai.ac.jp

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2022-06-16  

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