Research Project
Grant-in-Aid for Young Scientists (B)
During cortical development in mammals, neural stem/progenitor cells need to adequately proliferate and differentiate. Neural progenitor cells during corticogenesis are called radial glial (RG) cells because they show highly polarized morphology with long and thin processes. We have previously shown that mRNA of Cyclin D2 encoding a cell cycle regulator is transported to the basal end-foot of RG cells by the specific mRNA transportation element. We applied a CRISPR/Cas9 genome editing system in mouse embryos and selectively removed the element. We found that the mutant mice show inhibition of Cyclin D2 mRNA transportation to the basal end-foot of RG cells. These results suggest involvement of the mammalian specific cis-regulatory sequence of Cyclin D2 mRNA in the mRNA transportation to the basal end-foot of RG cells.
All 2018 2017 2016
All Journal Article (5 results) (of which Peer Reviewed: 5 results, Open Access: 2 results) Presentation (6 results)
Brain Research
Volume: - Pages: 30111-2
10.1016/j.brainres.2018.02.041
Dev Growth Differ
Volume: 59 Issue: 9 Pages: 701-712
10.1111/dgd.12411
Curr Protoc Neurosci.
Volume: 78 Issue: 1 Pages: 1-16
10.1002/cpns.21
Journal of Anatomy
Volume: 230 Issue: 3 Pages: 373-380
10.1111/joa.12572
PLoS One
Volume: 11 Issue: 6 Pages: e0158153-e0158153
10.1371/journal.pone.0158153
