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Principle for controlling "changeable Young's modulus"-biofunctionality in biomedical titanium alloys for spinal fixation applications

Research Project

Project/Area Number 16K20918
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Material processing/Microstructural control engineering
Structural/Functional materials
Research InstitutionOsaka University

Principal Investigator

LIU HUIHONG  大阪大学, 接合科学研究所, 助教 (40748943)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords生体用チタン合金 / 弾性率自己調整 / 変形誘起ω相変態 / 脊椎固定器具 / Metallic biomaterials / Titanium alloys / Deformation twinning / Dislocation gliding / Omega transformation / Re-orientation / Tensile deformation / 構造・機能材料 / 生体・医療・福祉材料 / 組織制御
Outline of Final Research Achievements

When and how the deformation-induced omega phase transformation occurs and how it affects mechanical properties during tensile deformation was investigated in the spinal-support alloy, Ti-9Cr-0.2O. The deformation-induced omega phase transformation can be triggered by elastic strain or stress without plastic deformation. Under further deformation, the omega1 variant may re-orientate into omega2 variant via twinning-type mechanism. During tensile deformation, the strengthening effect induced by omega phase increases when strained to 7%, then decreases with further increasing strain. This result is likely correlated with the omega particle coarsening, the omega variant re-orientation and the possible reserve transformation of omega phase to beta phase during tensile deformation. These obtained findings not only contributes to materials science, but also might guide us to develop the novel biomedical titanium alloys with significant changeable Young’s modulus bio-functionality.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (33 results)

All 2018 2017 2016

All Journal Article (17 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 17 results,  Acknowledgement Compliant: 2 results) Presentation (15 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Microstructural and mechanical properties of a beta-type titanium alloy joint fabricated by friction stir welding2018

    • Author(s)
      H.H. Liu, H. Fujii
    • Journal Title

      Materials Science and Engineering: A

      Volume: 711 Pages: 140-148

    • DOI

      10.1016/j.msea.2017.11.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heat Treatment to Improve Fatigue Strength of Friction Stir Welded Ti-6Al-4V Alloy Butt Joint2017

    • Author(s)
      M. Nakai, M. Niinomi, Y. Ishida, H.H. Liu, H. Fujii, T. Ninomiya
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 58 Issue: 8 Pages: 1223-1226

    • DOI

      10.2320/matertrans.M2017117

    • NAID

      130005858774

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved fatigue properties with maintaining low Young’s modulus achieved in biomedical beta-type titanium alloy by oxygen addition2017

    • Author(s)
      H.H. Liu, M. Niinomi, M. Nakai, S. Obara, H. Fujii
    • Journal Title

      Materials Science and Engineering: A

      Volume: 704 Pages: 10-17

    • DOI

      10.1016/j.msea.2017.07.078

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal Deformation Behavior of Oxygen-added Beta-type Ti-29Nb-13Ta-4.6Zr Alloys for Biomedical Applications2017

    • Author(s)
      H. Liu, M. Niinomi, M. Nakai, X. Cong, K. Cho, C. J. Boehlert, and V. Khademi.
    • Journal Title

      Met. Mater. Trans. A

      Volume: 48 Issue: 1 Pages: 139-149

    • DOI

      10.1007/s11661-016-3836-5

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Deformation-induced ω-phase transformation in a β-type titanium alloy during tensile deformation2017

    • Author(s)
      Huihong Liu, MitsuoNiinomi, Masaaki Nakai, Ken Cho, Hidetoshi Fujii
    • Journal Title

      Scripta Materialia

      Volume: 130 Pages: 27-31

    • DOI

      10.1016/j.scriptamat.2016.10.036

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improvement in mechanical strength of low-cost beta-type Ti-Mn alloys fabricated by metal injection molding through cold rolling2016

    • Author(s)
      K. Cho, M. Niinomi, M. Nakai, H.H. Liu, P.F. Santos, Y. Itoh, M. Ikeda, M. abdel-hady Gepreel, T. Narushima
    • Journal Title

      Journal of Alloys and Compounds

      Volume: 664 Pages: 272-283

    • DOI

      10.1016/j.jallcom.2015.12.200

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fabrication of low-cost beta-type Ti-Mn alloys for biomedical applications by metal injection molding process and their mechanical properties2016

    • Author(s)
      P.F. Santos, M. Niinomi, H.H. Liu, K. Cho, M. Nakai, Y. Itoh, T. Narushima, M. Ikeda
    • Journal Title

      Journal of the Mechanical Behavior of Biomedical Materials

      Volume: 59 Pages: 497-507

    • DOI

      10.1016/j.jmbbm.2016.02.035

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microstructural evolution and mechanical properties of biomedical Co-Cr-Mo alloy subjected to high-pressure torsion2016

    • Author(s)
      M. Isik, M. Niinomi, K. Cho, M. Nakai, H. Liu, H. Yilmazer, Z. Horita, T. Narushima
    • Journal Title

      Journal of the Mechanical Behavior of Biomedical Materials

      Volume: 59 Pages: 226-235

    • DOI

      10.1016/j.jmbbm.2015.11.015

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Grain Refinement Mechanism and Evolution of Dislocation Structure of Co–Cr–Mo Alloy Subjected to High-Pressure Torsion2016

    • Author(s)
      Murat Isik, Mitsuo Niinomi, Huihong Liu, Ken Cho, Masaaki Nakai, Zenji Horita, Shigeo Sato, Takayuki Narushima, Hakan Yilmazer, Makoto Nagasako
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 57 Issue: 7 Pages: 1109-1118

    • DOI

      10.2320/matertrans.M2016052

    • NAID

      130005158387

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Improvement of microstructure, mechanical and corrosion properties of biomedical Ti-Mn alloys by Mo addition2016

    • Author(s)
      P.F. Santos, M. Niinomi, H. Liu, K. Cho, M. Nakai, A. Trenggono, S. Champagne, H. Hermawan, T. Narushima
    • Journal Title

      Materials & Design

      Volume: 110 Pages: 414-424

    • DOI

      10.1016/j.matdes.2016.07.115

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Optimization of Microstructure and Mechanical Properties of Co–Cr–Mo Alloys by High-Pressure Torsion and Subsequent Short Annealing2016

    • Author(s)
      Murat Isik, Mitsuo Niinomi, Huihong Liu, Ken Cho, Masaaki Nakai, Zenji Horita, Takayuki Narushima, Kyosuke Ueda
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 57 Issue: 11 Pages: 1887-1896

    • DOI

      10.2320/matertrans.M2016112

    • NAID

      130005290023

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of Solute Oxygen on Compressive Fatigue Strength of Spinal Fixation Rods Made of Ti–29Nb–13Ta–4.6Zr Alloys2016

    • Author(s)
      Y.-S. Lee, M. Niinomi, M. Nakai, K. Narita and H.H. Liu
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 57 Issue: 12 Pages: 1993-1997

    • DOI

      10.2320/matertrans.MI201504

    • NAID

      130005284458

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of New Ti-Mn-Mo Alloys for Use in Biomedical Applications2016

    • Author(s)
      Pedro Santos, Mitsuo Niinomi, Ken Cho, Masaaki Nakai, Huihong Liu
    • Journal Title

      Proceedings of the 13th World Conference on Titanium

      Volume: - Pages: 1741-1745

    • DOI

      10.1002/9781119296126.ch293

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tensile and Compressive Properties of Low-Cost High-Strength β-Type Ti-Mn Alloys Fabricated by Metal Injection Molding2016

    • Author(s)
      Ken Cho, Mitsuo Niinomi, Masaaki Nakai, Huihong Liu, Pedro Fernandes Santos, Yoshinori Itoh, Masahiko Ikeda
    • Journal Title

      Proceedings of the 13th World Conference on Titanium

      Volume: - Pages: 499-503

    • DOI

      10.1002/9781119296126.ch79

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of Biomedical Titanium Alloys with a Focus on Controlling Young’s Modulus2016

    • Author(s)
      Mitsuo Niinomi, Masaaki Nakai, Huihong Liu and Ken Cho
    • Journal Title

      Proceedings of the 13th World Conference on Titanium

      Volume: - Pages: 1655-1663

    • DOI

      10.1002/9781119296126.ch277

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Wear Behaviors of Combinations Comprised of Titanium Alloys in Air and Ringer’S Solution2016

    • Author(s)
      Masaaki Nakai, Mitsuo Niinomi, Kengo Narita, Ken Cho, Huihong Liu, Yoon-Seok Lee
    • Journal Title

      Proceedings of the 13th World Conference on Titanium

      Volume: - Pages: 1707-1710

    • DOI

      10.1002/9781119296126.ch286

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] A β-Type Titanium Alloy With Significantly Changeable Young’S Modulus and Good Mechanical Properties Used for Spinal Fixation Applications2016

    • Author(s)
      Huihong Liu, Mitsuo Niinomi, Masaaki Nakai, Ken Cho, Kengo Narita
    • Journal Title

      Proceedings of the 13th World Conference on Titanium

      Volume: - Pages: 1685-1689

    • DOI

      10.1002/9781119296126.ch282

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 界面観察によるCuの摩擦攪拌接合における接合機構の解明2018

    • Author(s)
      劉 恢弘、藤井 英俊
    • Organizer
      日本金属学会第162回春期講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 放射光X線を利用したAl-Cu合金のTIG溶接における凝固割れのその場観察2018

    • Author(s)
      柳楽 知也、山下 大輔、釜井 正善、青木 祥宏、劉 恢弘、藤井 英俊
    • Organizer
      日本金属学会第162回春期講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 摩擦攪拌接合により作製したβ型チタン合金継手の微細組織及び機械的特性2017

    • Author(s)
      劉 恢弘, 藤井 英俊
    • Organizer
      日本金属学会 2017年春期大会
    • Place of Presentation
      東京,日本
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Microstructure and mechanical properties of beta-type Ti-15V-3Cr-3Al-3Sn alloy joints fabricated by friction stir welding2017

    • Author(s)
      Huihong Liu, Hidetoshi Fujii
    • Organizer
      Friction Stir Welding and Processing IX, 2017 TMS Annual Meeting & Exhibition
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2017-02-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 摩擦攪拌接合により作製したβ型チタン合金継手の微細組織及び機械的特性2017

    • Author(s)
      劉 恢弘、藤井 英俊
    • Organizer
      (一社)溶接学会 平成29年度春季全国大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 低温摩擦圧接時の高速度鋼継手における接合温度制御方法2017

    • Author(s)
      青木 洋、青木 祥宏、劉 恢弘、藤井 英俊
    • Organizer
      (一社)溶接学会 平成29年度春季全国大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Friction Welding of High-Speed Steel at Low Temperture2017

    • Author(s)
      Yo AOKI, Yasuhiro AOKI, Huihong LIU, Hidetoshi FUJII
    • Organizer
      2017 International Congress on Welding, Additive Manufacturing and associated non-destructive testing
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 摩擦攪拌接合したβ型チタン合金継手の微細組織及び機械的特性に及ぼす液体CO2冷却の影響2017

    • Author(s)
      劉 恢弘、藤井 英俊
    • Organizer
      (一社)溶接学会 平成29年度秋季全国大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 純チタン/純アルミニウムにおける異材摩擦攪拌接合2017

    • Author(s)
      崔 正原、劉 恢弘、藤井 英俊
    • Organizer
      (一社)溶接学会 平成29年度秋季全国大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 摩擦圧接によるTi-6Al-4V/SUS316Lの異材接合2017

    • Author(s)
      青木 洋、青木 祥宏、劉 恢弘、藤井 英俊
    • Organizer
      (一社)溶接学会 平成29年度秋季全国大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Optimize The Microstructure and Mechanical Properties of High Pressure Torsion Processed Co-Cr-Mo Alloy by Short Annealing2017

    • Author(s)
      Huihong Liu, Murat Isik, Mitsuo Niinomi, Peng Chen, Takao Hanawa, Tomoya Nagira, Hidetoshi Fujii
    • Organizer
      The 2nd International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development (iLIM-2)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidation of microstructural evolution of friction stir welded beta-type titanium alloy joint by using liquid CO2 cooling2017

    • Author(s)
      Huihong Liu, Hidetoshi Fujii
    • Organizer
      3rd International Conference on Friction Based Processes (ICFP2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Solution treatment and again on fatigue strength of friction stir welded Ti-6Al-4V alloy butt joint2017

    • Author(s)
      Masaaki Nakai, Mitsuo Niinomi, Huihong Liu,Hidetoshi Fujii
    • Organizer
      3rd International Conference on Friction Based Processes (ICFP2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microstructure and Mechanical Properties of a Biomedical Co-Cr-Mo Alloy Processed by High Pressure Torsion2016

    • Author(s)
      Huihong LIU, Murat ISIK, Mitsuo NIINOMI, Peng CHEN, Takao HANAWA, Hidetoshi FUJII
    • Organizer
      The 1st International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development (iLIM-1)
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2016-10-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Microstructural and texture evolution in Ti-6Al-4V joints fabricated by friction stir welding below beta-transus temperature2016

    • Author(s)
      Huihong Liu, Yoshiaki Morisada, Hidetoshi Fujii
    • Organizer
      2016 International Symposium for Advanced Materials Research (ISAMR 2016)
    • Place of Presentation
      Sun Moon Lake, Taiwan
    • Year and Date
      2016-08-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] Interface Oral Health Science 20162016

    • Author(s)
      Pedro Fernandes Santos, Mitsuo Niinomi, Huihong Liu, Masaaki Nakai, Ken Cho, Takayuki Narushima, Kyosuke Ueda, Naofumi Ohtsu, Mitsuhiro Hirano, Yoshinori Itoh
    • Total Pages
      16
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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