• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Transition of the circuit usage for memory processing

Research Project

Project/Area Number 16K20919
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Animal physiology/Animal behavior
Research InstitutionNagoya City University (2017-2018)
Tohoku University (2016)

Principal Investigator

Ichinose Toshiharu  名古屋市立大学, 大学院薬学研究科, 研究員 (20774748)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords記憶学習 / ショウジョウバエ / キノコ体出力神経 / ドーパミン / キノコ体 / 連合学習 / 神経回路 / 短期記憶 / 長期記憶 / 記憶の読み出し回路
Outline of Final Research Achievements

The mushroom body (MB) of Drosophila melanogaster is functionally pleiotropic. However, circuit mechanisms that generate this pleiotropy are largely unclear. Here, we systematically probed the behavioral requirement of each type of MB output neurons (MBON) for appetitive or aversive memories. We evaluated the requirement using two conditioned responses: memory-guided odor choice and odor source attraction. Quantitative analysis revealed that these conditioned odor responses are controlled by distinct sets of MBONs. We found that the valence of memory, rather than the transition of memory steps, has a larger impact on the MB output patterns. Our results provide principles how the MB processes associative memories of different valence and distinct memory-guided behaviors.

Academic Significance and Societal Importance of the Research Achievements

海馬や扁桃体といった脳の高次構造は一般的に、記憶、場所情報や感情といった様々な情報を処理する。しかし、そのような多機能性がどのように実現されているか、その詳細は不明である。ショウジョウバエのキノコ体も同様に、様々な記憶情報を処理する。キノコ体を構成する神経細胞は、そのほぼ全てが明らかになっており、一細胞レベルで機能操作することができるため、キノコ体をモデルに多機能性の仕組みを解き明かすことができる。本研究は、この全ての細胞を対象に、報酬記憶と罰記憶に基づいた様々な記憶発現を行う神経回路を網羅的に同定した。この成果により、多機能性を実現する神経回路構造の詳細を明らかにすることができた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Behavioral modulation by spontaneous activity of dopamine neurons.2017

    • Author(s)
      Toshiharu Ichinose, Hiromu Tanimoto, Nobuhiro Yamagata
    • Journal Title

      Frontiers Systems Neuroscience

      Volume: 11 Pages: 88-88

    • DOI

      10.3389/fnsys.2017.00088

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spontaneous activity of dopamine neurons and its role in behavioral regulation2017

    • Author(s)
      市之瀬 敏晴, 山方 恒宏
    • Journal Title

      Hikaku seiri seikagaku(Comparative Physiology and Biochemistry)

      Volume: 34 Issue: 4 Pages: 108-115

    • DOI

      10.3330/hikakuseiriseika.34.108

    • NAID

      130006847566

    • ISSN
      0916-3786, 1881-9346
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dynamics of memory-guided choice behavior in <i>Drosophila</i>2016

    • Author(s)
      Rohwedder A, Wenz NL, Stehle B, Huser A, Yamagata N, Zlatic M, Truman JW, Tanimoto H, Saumweber T, Gerber B.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 92 Issue: 8 Pages: 346-357

    • DOI

      10.2183/pjab.92.346

    • NAID

      130005420972

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Direct neural pathways convey distinct visual information to Drosophila mushroom bodies.2016

    • Author(s)
      Vogt K, Aso Y, Hige T, Knapek S, Ichinose T, Friedrich AB, Turner GC, Rubin GM, Tanimoto H.
    • Journal Title

      eLife

      Volume: in press

    • DOI

      10.7554/elife.14009

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Chronic poor condition enhances preference for rewarding substances2018

    • Author(s)
      Ichinose T, Kanno M, Abe A, Tanimoto H.
    • Organizer
      3th Japanese Drosophila Research Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chronic poor condition enhances preference for rewarding substances through dopamine system2018

    • Author(s)
      Ichinose T, Kanno M, Kondo S, Hiramatsu S, Abe A, Tanimoto H.
    • Organizer
      Asia-pacific Drosophila neurobiology conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visualization and neuronal control of memory-guided choice behaviour.2017

    • Author(s)
      Kanno M, Ichinose T, Onodera Y, Sirigrivatanawong P, Hashimoto K, Yamagata N, Tanimoto H.
    • Organizer
      Janelia Farm Conference “Structure and Function of the Insect Mushroom Body”
    • Place of Presentation
      Janelia Research Campus, Verginia, USA
    • Year and Date
      2017-03-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neural circuits that distinguish memory processes in the fly brain2017

    • Author(s)
      Toshiharu Ichinose, Mai Kanno, Hiromu Tanimoto
    • Organizer
      15th European Symposium for insect Taste and Olfaction (15th ESITO)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neural circuits that distinguish memory processes in the fly brain2017

    • Author(s)
      Toshiharu Ichinose, Mai Kanno, Hiromu Tanimoto
    • Organizer
      4th Asia-Pacific Drosophila Research Conference (APDRC4)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi