Systematic Synthesis of Fluorine-Containing Compounds via Transition Metal-Catalyzed Fluorine Elimination
| Project/Area Number |
16K20939
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Organic chemistry
Synthetic chemistry
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | 有機合成化学 / フッ素 / 金属触媒 / 有機金属化学 / 触媒 / 有機化学 |
|---|
| Outline of Final Research Achievements |
I established a methodology for the catalytic synthesis of fluorine-containing compounds by applying metal-mediated fluorine elimination to a wide variety of organometallic reactions. Rational combination of typical organometallic elementary steps with fluorine elimination processes enabled catalytic C-F bond activation. Herein, I mainly utilized (i) electrophilic activation of unsaturated bonds, (ii) oxidative cyclization, and (iii) an oxidative addition-insertion sequence, for the setup of organometallic intermediates suitable for fluorine elimination. Although, in such cases, inert metal fluorides were formed during reactions, I succeeded in regeneration of catalytically active species by addition of appropriate reagents.
|
Report
(3 results)
Research Products
(32 results)
-
-
-
-
-
[Journal Article] Facile Synthesis of Polycyclic Aromatic Hydrocarbons: Bronsted Acid-Catalyzed Dehydrative Cycloaromatization of Carbonyl Compounds in 1,1,1,3,3,3- Hexafluoropropan-2-ol2017
Author(s)
Fujita, T.; Takahashi, I.; Hayashi, M.; Wang, J.; Fuchibe, K.; Ichikawa, J.
-
Journal Title
European Journal of Organic Chemistry
Volume: 2
Issue: 2
Pages: 262-265
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
