| Project/Area Number |
16K20939
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
Synthetic chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 有機合成化学 / フッ素 / 金属触媒 / 有機金属化学 / 触媒 / 有機化学 |
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| Outline of Final Research Achievements |
I established a methodology for the catalytic synthesis of fluorine-containing compounds by applying metal-mediated fluorine elimination to a wide variety of organometallic reactions. Rational combination of typical organometallic elementary steps with fluorine elimination processes enabled catalytic C-F bond activation. Herein, I mainly utilized (i) electrophilic activation of unsaturated bonds, (ii) oxidative cyclization, and (iii) an oxidative addition-insertion sequence, for the setup of organometallic intermediates suitable for fluorine elimination. Although, in such cases, inert metal fluorides were formed during reactions, I succeeded in regeneration of catalytically active species by addition of appropriate reagents.
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