| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In this study, a mechanism to release an amine-containing compound by the action of neuraminidase has been constructed and applied to a chromogenic substrate and a lipid-soluble peptide. In the presence of neuraminidase, the prodrug-type substrates not only release amine-containing compounds but also reduce the activity of neuraminidase by side reaction with the intermediate generated in the process of release.
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