| Project/Area Number |
16K20963
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
Nerve anatomy/Neuropathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Miyamichi Kazunari 東京大学, 大学院農学生命科学研究科(農学部), 特任准教授 (30612577)
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| Research Collaborator |
Ishii Kentaro 東京大学, 大学院農学生命科学研究科, 大学院生
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 性的二形 / 神経回路 / フェロモン / 性行動 / 視床下部 / 扁桃体 / 性的二形性 / 内側扁桃体 / 経路選択的操作 / 嗅覚 / 投射特異性 |
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| Outline of Final Research Achievements |
In mice, chemosensory signals derived from mates or predators evoke stereotyped behavioral responses such as sexual or defensive behaviors. How a specific sensory input is converted to a stereotyped behavioral output remained elusive. In this study, we mapped responsible neural circuit for enhanced sexual behaviors of adult female mice induced by a male-specific sex pheromone called ESP1. In the medial amygdala, ESP1 activated distinct projection neurons depending on the sex of recipient mice. In hypothalamus, ESP1 and a predator’s signal (snake skin) were mediated by mostly non-overlapping neurons that were intermingled in the same brain region. Together, these data revealed the presence of labeled-line organization for processing the sensory signals that evokes innate behavioral outputs.
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