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Neural basis for pathway-selective activation of amygdala

Research Project

Project/Area Number 16K20963
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Nerve anatomy/Neuropathology
Research InstitutionThe University of Tokyo

Principal Investigator

Miyamichi Kazunari  東京大学, 大学院農学生命科学研究科(農学部), 特任准教授 (30612577)

Research Collaborator Ishii Kentaro  東京大学, 大学院農学生命科学研究科, 大学院生
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords性的二形 / 神経回路 / フェロモン / 性行動 / 視床下部 / 扁桃体 / 性的二形性 / 内側扁桃体 / 経路選択的操作 / 嗅覚 / 投射特異性
Outline of Final Research Achievements

In mice, chemosensory signals derived from mates or predators evoke stereotyped behavioral responses such as sexual or defensive behaviors. How a specific sensory input is converted to a stereotyped behavioral output remained elusive. In this study, we mapped responsible neural circuit for enhanced sexual behaviors of adult female mice induced by a male-specific sex pheromone called ESP1. In the medial amygdala, ESP1 activated distinct projection neurons depending on the sex of recipient mice. In hypothalamus, ESP1 and a predator’s signal (snake skin) were mediated by mostly non-overlapping neurons that were intermingled in the same brain region. Together, these data revealed the presence of labeled-line organization for processing the sensory signals that evokes innate behavioral outputs.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results) Book (1 results) Remarks (2 results)

  • [Journal Article] A Labeled-Line Neural Circuit for Pheromone-Mediated Sexual Behaviors in Mice2017

    • Author(s)
      Ishii Kentaro K.、Osakada Takuya、Mori Hiromi、Miyasaka Nobuhiko、Yoshihara Yoshihiro、Miyamichi Kazunari、Touhara Kazushige
    • Journal Title

      Neuron

      Volume: 95 Issue: 1 Pages: 123-137

    • DOI

      10.1016/j.neuron.2017.05.038

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] ウイルス遺伝子工学を用いた神経回路構造の研究2017

    • Author(s)
      宮道和成
    • Organizer
      日本神経科学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Functional Dissection of Hypothalamus by Sex Pheromones in Mice2017

    • Author(s)
      Kazunari Miyamichi
    • Organizer
      日本神経科学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] フェロモンによる生殖抑制の神経基盤2017

    • Author(s)
      宮道和成
    • Organizer
      第4回 Chemosensation and Behavior研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] マウスにおける性フェロモンの神経作用メカニズム2017

    • Author(s)
      宮道和成
    • Organizer
      第1回 性と生殖の懇談会 2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 神経回路マッピングは 神経疾患の理解に役立つか?2017

    • Author(s)
      宮道和成
    • Organizer
      第2回 CDBこども病院ジョイントシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] マウスにおける経路選択的なウイルス遺伝子工学を用いた高次嗅覚神経回路の解析2016

    • Author(s)
      宮道和成
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Dissecting neural circuits processing a sex pheromone in mice2016

    • Author(s)
      Kazunari Miyamichi
    • Organizer
      17th International Symposium on Olfaction and Taste
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2016-06-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] Connectivity and Circuit Architecture Using Transsynaptic Tracing in Vertebrates2017

    • Author(s)
      Kazunari Miyamichi and Lindsay A. Schwarz
    • Total Pages
      57
    • Publisher
      Springer
    • ISBN
      9783319573625
    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京大学大学院農学生命科学研究科 プレスリリース

    • URL

      http://www.a.u-tokyo.ac.jp/topics/2017/20170626-1.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] マウスの性フェロモンESP1がメスの性行動を促進するための専用の神経回路 (新着論文レビュー)

    • URL

      http://first.lifesciencedb.jp/archives/16645

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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