Network meta-analysis in diabetes

• Project/Area Number: 16K20965
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine; Hygiene and public health
• Research Institution: The University of Tokyo
• Principal Investigator: Yamada Tomohide 東京大学, 医学部附属病院, 登録研究員 (10755705)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ネットワークメタアナリシス / メタアナリシス / 糖尿病 / 心血管疾患 / 肥満 / 人工知能 / 系統的レビュー / 根拠に基づく医療

Outline of Final Research Achievements

Network meta-analysis is a method that pools evidence from randomised controlled trials that compare two or more treatments, but where each trial may compare different treatments. Network meta-analysis allows one to simultaneously estimate relative effectiveness for any pair of treatments in the evidence network.
We performed some network meta-analyses to assess the efficacy and safety of treatments in diabetes.

Academic Significance and Societal Importance of the Research Achievements

本研究の目的は、ネットワークメタアナリシスの手法を用いて、糖尿病領域における質の高いランダム化比較試験について、治療法間での治療効果や安全性の比較を行うことである。
世界の糖尿病・生活習慣病に関するランダム化比較試験を統合し、診療ガイドラインの策定に有益なエビデンスを提供することで、世界の糖尿病の治療・予防ガイドラインの礎となる。

Research Products

• [Journal Article] Biosimilar Versus Originator Insulins: Systematic review and meta-analysis (2018)
  • Author(s): Yamada Tomohide、Kamata Ryuichi、Ishinohachi Kotomi、Shojima Nobuhiro、Ananiadou Sophia、Noma Hisashi、Yamauchi Toshimasa、Kadowaki Takashi
  • Journal Title: Diabetes Obes Metab Volume: in press Issue: 7 Pages: 1787-1792
  • DOI: 10.1111/dom.13291
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sodium-glucose co-transporter 2 (SGLT2) inhibitors as add-on therapy to insulin for type 1 diabetes mellitus: Systematic review and meta-analysis of randomized controlled trials (2018)
  • Author(s): Yamada Tomohide、Shojima Nobuhiro、Noma Hisashi、Yamauchi Toshimasa、Kadowaki Takashi
  • Journal Title: Diabetes Obes Metab Volume: in press Issue: 7 Pages: 1755-1761
  • DOI: 10.1111/dom.13260
  • Peer Reviewed
• [Journal Article] Weekly Versus Daily Dipeptidyl Peptidase 4 Inhibitor Therapy for Type 2 Diabetes: Systematic Review and Meta-analysis. (2018)
  • Author(s): Yamada T, Shojima N, Noma H, Yamauchi T, Kadowaki T
  • Journal Title: Diabetes Care Volume: 41 Issue: 4 Pages: e52-e55
  • DOI: 10.2337/dc17-2095
  • Peer Reviewed
• [Journal Article] Glycemic control, mortality, and hypoglycemia in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials. (2017)
  • Author(s): Yamada T, Shojima N, Noma H, Yamauchi T, Kadowaki T.
  • Journal Title: Intensive Care Medicine Volume: 43 Issue: 1 Pages: 1-15
  • DOI: 10.1007/s00134-016-4523-0
  • Peer Reviewed / Open Access
• [Journal Article] Achieved glucose level and mortality risk in randomized clinical trials (2017)
  • Author(s): Yamada T
  • Journal Title: Resuscitation Volume: 110 Pages: e3-e4
  • DOI: 10.1016/j.resuscitation.2016.10.011
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Glycemic control, mortality, secondary infection, and hypoglycemia in critically ill pediatric patients: A systematic review and network meta-analysis of randomized controlled trials (2017)
  • Author(s): 3.Yamada T, Shojima N, Hara K, Noma H, Yamauchi T, Kadowaki T.
  • Journal Title: Intensive Care Medicine. Volume: 印刷中 Issue: 9 Pages: 1427-1429
  • DOI: 10.1007/s00134-017-4801-5
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] J-curve relation between daytime nap duration and type 2 diabetes or metabolic syndrome: A dose-response meta-analysis. (2016)
  • Author(s): Yamada T, Shojima N, Yamauchi T, Kadowaki T
  • Journal Title: Scientific Report Volume: 6 Issue: 1 Pages: 38075-38075
  • DOI: 10.1038/srep38075
  • Peer Reviewed / Open Access