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Molecular analysis of bone marrow failure syndrome modeled on donor derived bone marrow failure syndrome

Research Project

Project/Area Number 16K20973
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hematology
Tumor biology
Research InstitutionNational Hospital Organization Nagoya Medical Center

Principal Investigator

Yasuda Takahiko  独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, その他 (20723977)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords骨髄不全症候群 / 造血幹細胞移植 / ドナー由来 / 全エクソン解析 / ドナー由来骨髄不全症候群 / T細胞レパトア解析 / 同種造血幹細胞移植 / ゲノム
Outline of Final Research Achievements

We experienced four patients with bone marrow failure syndrome after allogeneic stem cell transplantation who sustain donor derived hematopoiesis. We aim to clarify a molecular mechanisms for development of bone marrow failure syndrome using specimens of patients of donor derived bone marrow failure syndrome. Whole exome sequencing revealed 5-10 somatic mutation with low allele frequencies in each patients. Low burden of clonal hematopoiesis with somatic mutations might be a characteristics of this complications after allogeneic stem cell transplantation.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (15 results)

All 2017 2016

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (3 results)

  • [Journal Article] Acute lymphoblastic leukemia of adolescents and young adults: from the viewpoint of physicians2017

    • Author(s)
      安田 貴彦、早川 文彦
    • Journal Title

      Rinsho Ketsueki

      Volume: 58 Issue: 8 Pages: 1031-1037

    • DOI

      10.11406/rinketsu.58.1031

    • NAID

      130006067964

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency2017

    • Author(s)
      Kawazu Masahito、Kojima Shinya、Ueno Toshihide、Totoki Yasushi、Nakamura Hiromi、Kunita Akiko et.al.
    • Journal Title

      PLOS Genetics

      Volume: 13 Issue: 6 Pages: e1006853-e1006853

    • DOI

      10.1371/journal.pgen.1006853

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PAX5 tyrosine phosphorylation by SYK co-operatively functions with its serine phosphorylation to cancel the PAX5-dependent repression of BLIMP1: A mechanism for antigen-triggered plasma cell differentiation.2016

    • Author(s)
      Inagaki Y, Hayakawa F, Hirano D, Kojima Y, Morishita T, Yasuda T, Naoe T, Kiyoi H
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 475 Issue: 2 Pages: 176-181

    • DOI

      10.1016/j.bbrc.2016.05.067

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Recurrent DUX4 fusions in B-cell acute lymphoblastic leukemia of adolescents and young adults.2016

    • Author(s)
      Yasuda T, Tsuzuki S, Kawazu M, Hayakawa F, Kojima S, Ueno T, Imoto N, Kohsaka S, Kunita A, Doi K, Sakura T, Yujiri T, Kondo E, Fujimaki K, Ueda Y, Aoyama Y, Ohtake S, Takita J, Sai E, Taniwaki M, Kurokawa M, Morishita S, Fukayama M, Kiyoi H, Miyazaki Y, Naoe T, Mano H.
    • Journal Title

      Nat Genet.

      Volume: 48 Issue: 12 Pages: 569-74

    • DOI

      10.1038/ng1216-1587a

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer2016

    • Author(s)
      Ando M, Kawazu M, Ueno T, Koinuma D, Ando K, Koya J, Kataoka K, Yasuda T, Yamaguchi H, Fukumura K, Yamato A, Soda M, Sai E, Yamashita Y, Asakage T, Miyazaki Y, Kurokawa M, Miyazono K, Nimer SD, Yamasoba T, Mano H.
    • Journal Title

      Cancer Res.

      Volume: 76 Issue: 7 Pages: 1814-1824

    • DOI

      10.1158/0008-5472.can-14-3816

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genomic characterization of primary central nervous system lymphoma2016

    • Author(s)
      Fukumura K, D Kawazu M, Ueno T, Sai E, Soda M, Kojima S, Ueda H, Yasuda T, Yamaguchi H, Lee J, Shishido-Hara Y, Sasaki A, Shirahata M, Mishima K, Ichimura K, Mukasa A, Narita Y, Saito N, Aburatani H, Nishikawa R, Nagane M, Mano H
    • Journal Title

      Acta Neuropathol

      Volume: publish online 12 Jan 2016 Issue: 6 Pages: 865-875

    • DOI

      10.1007/s00401-016-1536-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β2016

    • Author(s)
      Katsura A, Suzuki HI, Ueno T, Mihira H, Yamazaki T, Yasuda T, Watabe T, Mano H, Yamada Y, Miyazono K.
    • Journal Title

      Genes Cells

      Volume: 21 Issue: 1 Pages: 99-116

    • DOI

      10.1111/gtc.12323

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] High Expression of MEF2D-Fusion Protein Is Caused By Escaping from the Suppression By miRNA and Leads to Suppress Transcriptional Activity of PAX52017

    • Author(s)
      Daiki Hirano, Fumihiko Hayakawa, Takahiko Yasuda, naoyuki Tange, Hideyuki Yamamoto, Yuki Kojima, Takanobu Morishita, Naoto Imoto, Shinobu Tsuzuki, Hiroyuki Mano, Tomoki Naoe, Hitoshi Kiyoi
    • Organizer
      59th Annual Meeting of American Society of Hematology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The attempt to identify suitable MRD markers in acute lymphoblastic leukemia by next generation sequencing for practical use2017

    • Author(s)
      MitsukoAkaihata,YukaIijima,DaiNishijima,TomomiIshida,Mika Fuyama, Masaya Koganesawa, Takahiko Yasuda, Masashi Sanada
    • Organizer
      第59回小児血液がん学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] MEF2D 融合タンパクはマイクロ RNA の制御を 回避することで高発現になり PAX5 の転写活性 を抑制する2017

    • Author(s)
      Daiki Hirano, Fumihiko Hayakawa, Takahiko Yasuda, Hideyuki Yamamoto, Yuki Kojima, Takanobu Morishita, Naoto Imoto, Shinobu Tsuzuki, Hiroyuki Mano, Tomoki Naoe, Hitoshi Kiyoi
    • Organizer
      第79回日本血液学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 思春期・若年成人急性リンパ性白血病における新規融合型がん遺伝子DUX4-IGHの発見2016

    • Author(s)
      安田 貴彦、都築 忍、河津 正人、早川 文彦、小島 進也、上野 敏秀、清井 仁、直江 知樹、間野 博行
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] AYA世代急性リンパ性白血病における網羅的融合遺伝子解析2016

    • Author(s)
      安田 貴彦、都築 忍、河津 正人、早川 文彦、小島 進也、上野 敏秀、清井 仁、直江 知樹、間野 博行
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] 白血病診療の実際2017

    • Author(s)
      安田貴彦
    • Total Pages
      208
    • Publisher
      日本医師会雑誌
    • Related Report
      2016 Research-status Report
  • [Book] AYA世代ALLのゲノム異常2016

    • Author(s)
      安田貴彦
    • Total Pages
      211
    • Publisher
      腫瘍内科
    • Related Report
      2016 Research-status Report
  • [Book] Annual Review 20162016

    • Author(s)
      安田貴彦
    • Total Pages
      234
    • Publisher
      中外医学社
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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