Study on the organic nanofibers regulating the defects of calcite crystals in shells of Pinctada fucata
| Project/Area Number |
16K20995
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioorganic chemistry
Aquatic life science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Suzuki Michio 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (10647655)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アコヤガイ / 炭酸カルシウム / 結晶欠陥 / ナノファイバー / バイオミネラリゼーション / 有機基質 / 結晶成長 / 方解石 / 真珠 / キチン / 生理活性 / 応用動物 / 水産学 |
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| Outline of Final Research Achievements |
The organic nanofiber in the molluskan shells consists with chitin and chitinolytic enzymes. Studies using chitin nanofiber prepared by chitinolytic enzymes and inhibitor of chitinases revealed that chitin nanofiber induced the crystal defects in the process of calcite crystal growth. In this study, we showed that the nanofiber of chitin by chitinolytic enzymes increased the number of crystal defects and toughness of shells.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果により、アコヤガイの貝殻における有機物ナノファイバーの形成機構と機能が明らかとなった。有機物ナノファイバーを有効利用することができれば、真珠養殖後に大量に廃棄される貝殻の付加価値を高めた再利用法に開発に役立つ可能性が考えられる。また、キチン分解酵素を用いて繊維をナノ化し、結晶欠陥を制御することで新たな材料合成の開発に繋がる可能性が考えられる。
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] Structural and functional analyses of calcium ion response factors in the mantle of Pinctada fucata.2018
Author(s)
Akihiro Matsuura, Ko Yoshimura, Hiroyuki Kintsu, Takashi Atsumi, Yasushi Tsuchihashi, Takeshi Takeuchi, Noriyuki Satoh, Lumi Negishi, Shohei Sakuda, Tomiko Asakura, Yuki Imura and Etsuro Yoshimura Michio Suzuki.
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Journal Title
Journal of Structural Biology
Volume: 204(2)
Issue: 2
Pages: 240-249
DOI
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Peer Reviewed / Open Access
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[Journal Article] Search for aflatoxin and trichothecene production inhibitors and analysis of their modes of action2015
Author(s)
Shohei Sakuda, Tomoya Yoshinari, Tomohiro Furukawa, Usuma Jermnak, Keiko Takagi, Kurin Iimura, Toshiyoshi Yamamoto, Michio Suzuki, Hiromichi Nagasawa
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 80(1)
Issue: 1
Pages: 43-54
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Structural basis for the pH-dependent ferric ion coordination modes and conformations of the periplasmic iron binding protein FbpA from Thermus thermophilus HB82019
Author(s)
Peng LU, Yoshitaka Moriwaki, Yukie Katayama, Yi Lu, Ken Okamoto, Tohru Terada, Kentaro Shimizu, Mengyao Wang, Takehiro Kamiya, Toru Fujiwara, Michio Suzuki, Etsuro Yoshimura, Koji Nagata
Organizer
日本農芸化学会2019年度（平成31年度）大会
Related Report
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[Presentation] Study on the calcium ion response of Pinctada fucata in the sea water with high concentration of calcium ion.2016
Author(s)
Akihiro Matsuura, Ko Yoshimura, Takashi Atsumi, Yasushi Tsuchihashi, Takeshi Takeuchi, Noriyuki Sato, Lumi Negishi, Shohei Sakuda, Yuki Imura, Etsuro Yoshimura, ○Michio Suzuki.
Organizer
nd Interdisciplinary Symposium on Ocean Acidification and Climate Change
Place of Presentation
Hong Kong (China)
Year and Date
2016-12-06
Related Report
Int'l Joint Research / Invited
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