Investigation of behavior and cortical network for social causal attribution in primates

• Project/Area Number: 16K21042
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Brain biometrics; Basic / Social brain science
• Research Institution: Niigata University
• Principal Investigator: Adachi Yusuke 新潟大学, 医歯学系, 助教 (40625646)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 認知神経科学 / マカクザル / 神経科学 / 大脳皮質

Outline of Final Research Achievements

In daily life we always attribute the causes of personal events to self, other agents, or other entities. Because invasive researches in animals are indispensable to clarify the details of the neural mechanism of social causal attribution, it is necessary to construct a nonverbal behavioral task that is applicable to non-human animals. We constructed a behavior experiment system in which macaque monkeys had to judge what was the cause of good or bad events. It was confirmed that monkeys could adapt to the situation where the causal relationship changed in qualitative or quantitative manners. We also performed functional magnetic resonance imaging experiments in humans with an equivalent task and examined the brain regions related to causal attribution in this task.

Academic Significance and Societal Importance of the Research Achievements

社会的な原因帰属に偏りが生じることは健常者においてもしばしばあることだが、とくに統合失調症などの精神疾患で出来事の原因帰属に障害が伴うことが知られている。動物に適用可能な社会的原因帰属行動実験系を構築し、またヒトにおいて機能画像法を用いた関連脳領域の検討を行ったことにより、動物において侵襲的手法を用いたさらに詳細な生理学研究により社会的原因帰属行動の神経機構を解明する基盤となり、原因帰属の障害がみられる精神疾患の神経生理学的理解につながることが期待される。

Research Products

• [Journal Article] Dynamic laminar rerouting of inter-areal mnemonic signal by cognitive operations in primate temporal cortex (2018)
  • Author(s): Takeda, M., Hirabayashi, T., Adachi, Y., and Miyashita, Y.
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 4629-4629
  • DOI: 10.1038/s41467-018-07007-1
  • Peer Reviewed / Open Access
• [Journal Article] Causal neural network of metamemory for retrospection in primates (2017)
  • Author(s): Miyamoto, K., Osada, T., Setsuie, R., Takeda, M., Tamura, K., Adachi, Y., and Miyashita, Y.
  • Journal Title: Science Volume: 355 Issue: 6321 Pages: 188-193
  • DOI: 10.1126/science.aal0162
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] マカクザル及びヒトの質的・量的な因果構造理解に基づく自己に関わる出来事の原因帰属行動 (2019)
  • Author(s): 阿部湧，足立雄哉，田村滉樹，齊藤孝臣，飯島淳彦，長谷川功
  • Organizer: 第66回 中部日本生理学会
• [Presentation] Neural activations linking dual-step merge processes during comprehension of sequentially presented letterstrings: an fMRI study. (2019)
  • Author(s): Kasedo R, Iijima A, Nakahara K, Adachi Y, Homae F, Hashimoto R, Yamamoto K, Fukuda M, Shirozu H, Hasegawa I
  • Organizer: The 42nd Annual Meeting of the Japan Neuroscience Society Meeting
  • Int'l Joint Research
• [Presentation] 自己に関わる出来事の原因判断行動を検出するマカクザル実験パラダイム. (2018)
  • Author(s): 田村 滉樹, 足立 雄哉, 阿部 湧, 飯島 淳彦, 長谷川 功.
  • Organizer: 生体医工学シンポジウム
• [Presentation] fMRI を用いた文字から文への構造化プロセスに関わる脳領域の探索. (2018)
  • Author(s): 渡邊 諒太, 飯島 淳彦, 中原 潔, 白水 洋史, 福多 真史, 足立 雄哉, 長谷川 功.
  • Organizer: 生体医工学シンポジウム
• [Presentation] fMRIによる逐語的な文の階層構造築過程における脳内機構の解明 (2017)
  • Author(s): 岡本 俊輔, 渡邊 諒太, 飯島 淳彦, 中原 潔, 足立 雄哉, 長谷川 功
  • Organizer: 生体医工学シンポジウム2017
• [Presentation] Hierarchical prefrontal network arising from frontal pole area 10 during contextual memory retrieval in macaques. (2016)
  • Author(s): Osada T, Adachi Y, Miyamoto K, Jimura K, Setsuie R, Watanabe T, Miyashita Y
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Int'l Joint Research