| Project/Area Number |
16K21044
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
Infectious disease medicine
|
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| Research Institution | Osaka City University (2017)
Niigata University (2016) |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 高齢者結核 / 血清マーカー / 感染症 / 潜在性結核 |
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| Outline of Final Research Achievements |
In the presence of human serum, Mycobacterium tuberculsis and BCG cannot grow. In this study, we try to explore a novel anti-mycobacterial agent in human serum, which may suppress mycobacterial growth in healthy persons. We first expected that the exosomes in serum might be involved in this phenomenon, but serum exosomes did not have anti-mycobacterial effect. Rather, exosome-depleted serum could suppress mycobacterial growth. Anti-mycobacterial activity of exosome-depleted serum may be brought by anti-bacterial peptide, such as cathelicidin or defensin, and further examination is required.
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