Developmental study of neural basis responsible for language processing using diffusion tensor imaging

• Project/Area Number: 16K21050
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Basic / Social brain science; Neurophysiology / General neuroscience
• Research Institution: Hirosaki University
• Principal Investigator: Takahashi Michio 弘前大学, 医学研究科, 特任講師 (70760891)
• Research Collaborator: Matsui Mie
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 発達 / DTI / 下前頭回 / ブローカ野 / 脳構造の発達 / 言語野 / 神経科学 / 脳・神経

Outline of Final Research Achievements

The aim of this study is to elucidate the developmental trajectory from infancy to early adulthood of white matter in inferior frontal gyrus (IFG), which is critically related to language processing, using diffusion tensor image DTI. We calculated fractional anisotropy value (FA) and radial diffusivity value (RD) of white matter using MRIcloud in IFG and investigated the change of these value as growth and laterality. As a result, we demonstrated that FA in bilateral IFG rapidly increased by 50 months after birth and, then, the increase became gentle. We also showed the laterality with a higher FA in left IFG. This laterality in IFG suggests there is the superiority of left hemisphere, which may be related to language processing of left hemisphere, in the developmental period as well as adulthood.

Research Products

• [Journal Article] Differences in sleep problems between Japanese and Chinese preschoolers: a cross-cultural comparison within the Asian region (2018)
  • Author(s): Takahashi Michio、Wang Guanghai、Adachi Masaki、Jiang Fan、Jiang Yanrui、Saito Manabu、Nakamura Kazuhiko
  • Journal Title: Sleep medicine Volume: 印刷中 Pages: 42-48
  • DOI: 10.1016/j.sleep.2017.11.1145
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] rCBF and cognitive impairment changes assessed by SPECT and ADAS-cog in late-onset Alzheimer’s disease after 18?months of treatment with the cholinesterase inhibitors donepezil or galantamine (2017)
  • Author(s): Shirayama Yukihiko、Takahashi Michio、Oda Yasunori、Yoshino Kouhei、Sato Koichi、Okubo Toshiyuki、Iyo Masaomi
  • Journal Title: Brain Imaging and Behavior Volume: 印刷中 Issue: 1 Pages: 75-86
  • DOI: 10.1007/s11682-017-9803-y
  • Peer Reviewed
• [Journal Article] Coordination difficulties in preschool-aged children are associated with maternal parenting stress: A community-based cross-sectional study. (2017)
  • Author(s): Takahashi M, Adachi M, Takayanagi N, Yasuda S, Tanaka M, Osato-Kaneda A, Masuda T, Nakai A, Saito M, Kuribayashi M, Nakamura K
  • Journal Title: Research inDevelopmental Disabilities. Volume: 70 Pages: 11-23
  • DOI: 10.1016/j.ridd.2017.08.002
  • Peer Reviewed / Open Access
• [Journal Article] Myo-inositol, Glutamate, and Glutamine in the Prefrontal Cortex, Hippocampus, and Amygdala in Major Depression (2017)
  • Author(s): Shirayama Y, Takahashi M, Osone F, Hara A, OkuboT.
  • Journal Title: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Volume: 2 Issue: 2 Pages: 196-204
  • DOI: 10.1016/j.bpsc.2016.11.006
  • Peer Reviewed
• [Journal Article] Callosal size in first-episode schizophrenia patients with illness duration of less than one year: A cross-sectional MRI study (2017)
  • Author(s): Takahashi M, Matsui M, Nakashima M, Takahashi T, Suzuki M,
  • Journal Title: Asian Journal of Psychiatry Volume: 25 Pages: 197-202
  • DOI: 10.1016/j.ajp.2016.10.031
  • Peer Reviewed
• [Presentation] Developmental trajectory of gray matter in Broca's area from infancy to early adulthood. (2018)
  • Author(s): Takahashi Michio, Matsui Mie, Nakamura Kazuhiko
  • Organizer: 第44回日本脳科学会
• [Presentation] Developmental change of Broca's area from infancy to adulthood in healthy individual. (2016)
  • Author(s): Takahashi M, Nakashima M, Matsui M.
  • Organizer: The 31st International Congress of Psychology
  • Place of Presentation: Yokohama(Pacifico Yokohama)
  • Year and Date: 2016-07-24
  • Int'l Joint Research
• [Presentation] The morphological abnormality is absent in the corpus callosum of first-episode schizophrenia. (2016)
  • Author(s): Takahashi M, Matsui M, Nakashima M, Takahashi T, Suzuki M.
  • Organizer: The 39th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama(Pacifico Yokohama)
  • Year and Date: 2016-07-20
  • Int'l Joint Research
• [Book] How Humans Evolved Supersize Brains -The Growth of the Brain- (2016)
  • Author(s): Mie M, Yamashita A, Oishi K, Kawasaki Y, Wu D, Hiraiwa A, Aggarwal M, Zhang Y, Takahashi M, NishikawaY, Hamada Y, Sakai T
  • Total Pages: 75
  • Publisher: 一粒書房