| Project/Area Number |
16K21068
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
Laboratory medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
Kodaira Minori 信州大学, 学術研究院医学系(医学部附属病院), 助教 (60648012)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥1,053,000 (Direct Cost: ¥810,000、Indirect Cost: ¥243,000)
Fiscal Year 2017: ¥481,000 (Direct Cost: ¥370,000、Indirect Cost: ¥111,000)
Fiscal Year 2016: ¥572,000 (Direct Cost: ¥440,000、Indirect Cost: ¥132,000)
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| Keywords | 末梢神経障害 / 痛覚 / 痛覚関連脳電位 / 表皮内電気刺激法 / 表皮内電気刺激 / 小径末梢線維 / 神経生理学 |
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| Outline of Final Research Achievements |
We investigated clinical utility of intraepidermal electrical stimulation (IES) for evaluating small fiber (A-delta fiber) dysfunction. In patients with transthyretin familial amyloid polyneuropathy (ATTR-FAP) and healthy subjects, we evaluated pain threshold using IES and cold threshold using quantitative sensory testing (QST). Pain-related evoked potentials using IES were also analyzed. Pain threshold using IES was correlated with cold threshold using QST. Amplitude of pain-related evoked potentials was decreased with small fiber dysfunction in patients with ATTR-FAP. IES has a potential for a new clinical tool to evaluate small fiber dysfunction.
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