| Project/Area Number |
16K21069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
Immunology
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| Research Institution | Shinshu University |
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Principal Investigator |
JOSHITA SATORU 信州大学, 学術研究院医学系, 助教 (90597965)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 原発性胆汁性胆管炎 / IL-33 / ST2 / Autotaxin / sST2 / 原発性胆汁性肝硬変 / 病態 / 予後 |
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| Outline of Final Research Achievements |
Primary biliary cholangitis (PBC) is a slowly progressive liver-specific autoimmune disease. The pathogenesis and mechanism of PBC progression are incompletely understood. The key findings of this study were as follows; 1) the IL33/ST2 pathway was associated not only with pathogenesis, but also with disease progression, in patients with PBC. 2) Serum Autotaxin values appear to be useful for assessing disease stage and prognosis in PBC.
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