| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we successfully developed a method that can directly synthesize N-terminal thiazolidine-containing peptide thioester, which is an essential synthetic intermediate for complete chemical synthesis of proteins, from the corresponding hydrazide. This type of transformation has not been achieved by conventional methods. We also developed a novel solid-phase chemical ligation method for efficient protein synthesis, with peptide hydrazide as the key molecule. These results will find great utility in the preparation of useful artificial proteins.
|
