The role of retinoic acd signaling in endochondral ossification

• Project/Area Number: 16K21186
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry; Dental engineering/Regenerative dentistry
• Research Institution: Okayama University
• Principal Investigator: Uchibe Kenta 岡山大学, 医歯薬学総合研究科, 助教 (20584618)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: レチノイン酸 / 軟骨内骨化 / 軟骨 / 解剖学 / 骨格形成

Outline of Final Research Achievements

We performed in vitro and in vivo experiments to understand the role of retinoic acid signaling in endochondral ossification. Stimulation of RARγ signaling inhibited chondrocyte differentiation. Pharmacological inhibition of RARγ stimulated endochondral ossification both in vitro and in vivo, resulting in enhanced bone formation. Variety of signaling molecules are found to be involved in this process.

Research Products

• [Int'l Joint Research] The Children's Hospital of Philadelphia/University of Maryland/University of Pennsylvania(米国)
• [Int'l Joint Research] The Children's Hospital of Philadelphia/University of Pennsylvania(米国)
• [Journal Article] Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation (2016)
  • Author(s): Kenta Uchibe, Jiyeon Son, Colleen Larmour, Mourizio Pacifici, Motomi Enomoto-Iwamoto, Masahiro Iwamoto
  • Journal Title: Journal of orthopaedic research Volume: - Issue: 5 Pages: 1096-1105
  • DOI: 10.1002/jor.23347
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Drug-Based Growth Restriction of the Targeted Bone by Synthetic Retinoid Nanoparticles (2018)
  • Author(s): Masatake Matusoka, Kenta Uchibe, Ivan Alferiev, Joshua M. Abzug, Min Liu, Motomi Enomoto-Iwamoto, Michael Chorny, Masahiro Iwamoto
  • Organizer: ORS 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] RARγシグナリングは成長板軟骨細胞分化・成熟を制御する (2017)
  • Author(s): 内部健太、池亀美華、岡村裕彦
  • Organizer: 第５９回歯科基礎医学会学術大会
• [Presentation] Controlling Targeted Bone Growth by Retinoic Acid Receptor Gamma Agonist (2017)
  • Author(s): Masatake Matusoka, Kenta Uchibe, Ivan Alferiev, Joshua M. Abzug, Min Liu, Motomi Enomoto-Iwamoto, Michael Chorny, Masahiro Iwamoto
  • Organizer: ASBMR 2017 Annual Meeting
  • Int'l Joint Research