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Molecular mechanism of mammalian determination by histone modification

Research Project

Project/Area Number 16K21196
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Integrative animal science
Genome biology
Research InstitutionThe University of Tokushima

Principal Investigator

KUROKI Shunsuke  徳島大学, 先端酵素学研究所(次世代), 助教 (50735793)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords性決定 / エピゲノム / ヒストン修飾
Outline of Final Research Achievements

Development and differentiation is based on the precise control of gene expression. Epigenetic control by histone modifications and DNA methylation is indispensable for the spatio-temporal proper gene expression. We previously reported that Jmjd1a, one of the histone demethylases, plays a critical role for the expression of sex determination gene Sry in mouse embryos. For further knowledge of "the mammalian sex determinetion controlled by the epigenome", we have perfomed the following two projects, 1) Revealing the cooperative epigenetic control of Sry locus by H3K9 demethylase Jmjd1 family, 2) Searching for novel regulators for Sry locus.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance2017

    • Author(s)
      Shunsuke Kuroki, Naoki Okashita, Baba Shoko, Maeda Ryo, Shingo Miyawaki, Masashi Yano, Yamaguchi Miyoko, Kitano Satsuki, Miyachi Hitoshi, Itoh Akihiro, Yoshida Minoru and Makoto Tachibana
    • Journal Title

      PLoS Genetics

      Volume: 13(9) Issue: 9 Pages: 1-22

    • DOI

      10.1371/journal.pgen.1007034

    • NAID

      120006812002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Role of H3K9 methylation and demethylation enzymes in mouse development2017

    • Author(s)
      Shunsuke Kuroki and Makoto Tachibana
    • Organizer
      11th International Symposium of The Institute Network, Frontiers in Biomedical Sciences
    • Place of Presentation
      徳島大学(徳島県徳島市)
    • Year and Date
      2017-01-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Restoring the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance2017

    • Author(s)
      Shunsuke Kuroki
    • Organizer
      Asian Sex Differentiation Network (7th Gonad Biology Joint Meeting, 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒストンH3K9脱メチル化酵素Jmjd1a/b の機能解析2017

    • Author(s)
      黒木 俊介
    • Organizer
      新学術領域研究 3領域合同若手勉強会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of germ cell development by histone demethylation2016

    • Author(s)
      黒木 俊介, 立花 誠
    • Organizer
      1回次世代生命科学の研究会
    • Place of Presentation
      徳島大学(徳島県徳島市)
    • Year and Date
      2016-08-12
    • Related Report
      2016 Research-status Report
  • [Presentation] セルトリ細胞機能における ヒストンメチル化酵素Esetの役割2016

    • Author(s)
      黒木 俊介
    • Organizer
      新学術領域研究 "生殖細胞のエピゲノムダイナミクスとその制御" "ステムセルエイジングから解明する疾患原理" 合同若手勉強会2016
    • Place of Presentation
      亀の井ホテル(大分県別府市)
    • Year and Date
      2016-07-27
    • Related Report
      2016 Research-status Report
  • [Presentation] H3K9脱メチル化酵素Jmjd1aとJmjd1bによる雄性生殖細胞の発生制御2016

    • Author(s)
      黒木 俊介, 立花 誠
    • Organizer
      第10回日本エピジェネティクス研究会年会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府吹田市)
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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