The reserch for multiple organ dysfunction in neonatal hypoxic-ischemic encephalopathy

• Project/Area Number: 16K21202
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine; Emergency medicine
• Research Institution: Kagawa University
• Principal Investigator: Kubo Hiroyuki 香川大学, 医学部, 協力研究員 (30564116)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 新生仔豚 / 低酸素性虚血性脳症 / 多臓器障害 / 肝障害 / 腎障害 / 低体温治療 / 病理 / 新生児低酸素性虚血性脳症 / 臓器障害 / 新生児 / 低酸素

Outline of Final Research Achievements

Neonatal hypoxic-ischemic encephalopathy affects not only brain per se but also liver and kidney. Therapeutic hypothermia suppressed liver injury. Whereas, therapeutic hypothermia did not suppress kidney injury.
We consider that these results contribute to the establishment of treatment for neonatal hypoxic-ischemic encephalopathy.

Academic Significance and Societal Importance of the Research Achievements

新生児期の低酸素性虚血性脳症発症時には脳自体の障害だけでなく、同時に多臓器、特に肝臓、腎臓にも障害を来たすことを病理学的に証明した。また低体温治療は、肝障害予防には効果的に作用することが分かったが、一方、腎障害予防には繋がらない可能性が示唆された。
このことは新生児医療における低酸素性虚血性脳症児の管理の発展に寄与するものと考えられる。

Research Products

• [Journal Article] Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets. (2017)
  • Author(s): Kubo H, Shimono R, Nakamura S, Koyano K, Jinnai W, Yamato S, Yasuda S, Nakamura M, Tanaka A, Fujii T, Kanenishi K, Chiba Y, Miki T, Kusaka T, Ueno M.
  • Journal Title: Neonatology Volume: 111 Issue: 3 Pages: 203-210
  • DOI: 10.1159/000450721
  • Peer Reviewed / Open Access