The assessment of knee osteoarthritis using gagCEST imaging

• Project/Area Number: 16K21223
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science; Medical Physics and Radiological Technology
• Research Institution: Kyushu University
• Principal Investigator: Wada Tatsuhiro 九州大学, 大学病院, 診療放射線技師 (60444832)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 磁気共鳴医学 / 放射線医学

Outline of Final Research Achievements

We investigated the concentration dependence of chondroitin, the optimazation of scan parameters and correlation with T2map in glycosaminoglycan CEST (gagCEST) imaging, which is a type of endogenous CEST imaging.The positive correlation was observed between gagCEST imaging and chondroitin concentration.The signal intensity of gagCEST imaging were varied with saturation pulse strength and duration. The negative correlation was observed between gagCEST imaging and T2map.

Academic Significance and Societal Importance of the Research Achievements

変形性関節症治療の第一選択肢は保存療法であるが、症状が軽減しない場合には観血的治療の適応となる。そのため、軟骨変性を早期に発見することで観血的治療をさけることができれば患者のquality of lifeの向上が期待できる。
本研究は、glycosaminoglycan CEST(GagCEST)イメージングの基礎的な検討を行い、GagCESTイメージングが軟骨変性の早期発見を目的とした新たな画像診断法となる可能性を示した。

Research Products

• [Journal Article] Visualization of cerebrospinal fluid dynamics using multi-spin echo acquisition cine imaging (MUSACI) (2018)
  • Author(s): Wada Tatsuhiro、Tokunaga Chiaki、Togao Osamu、Funatsu Ryohei、Yamashita Yasuo、Kobayashi Kouji、Yoneyama Masami、Honda Hiroshi
  • Journal Title: Magnetic Resonance in Medicine Volume: 81 Issue: 1 Pages: 331-341
  • DOI: 10.1002/mrm.27394
  • Peer Reviewed
• [Presentation] TSE DIXON 法によるB0 補正を用いた短時間2D APT イメージングの基礎的検討 (2018)
  • Author(s): 徳永千晶，和田達弘，栂尾理，山下泰生，小林幸次，加藤豊幸
  • Organizer: 第45回日本磁気共鳴医学会大会
• [Presentation] Accuracy of 2D APT imaging with short acquisition time based on a self B0 correction using the TSE-Dixon method (2018)
  • Author(s): C Tokunaga, T Wada, O Togao, M Yoneyama, R Funatsu, Y Yamashita, K Kobayashi ,Y Umezu, H Honda
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB 2018
  • Int'l Joint Research
• [Presentation] Visualization of CSF dynamics using multi spin echo acquisition cine imaging (MUSACI) (2018)
  • Author(s): T Wada, C Tokunaga, O Togao, M Yoneyama, R Funatsu, Y Yamashita, K Kobayashi , T Kato
  • Organizer: The 2018 annual spring meeting of KRTA & international conference