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Effects of L-serine intake on circadian photoentrainment

Research Project

Project/Area Number 16K21225
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied anthropology
Applied health science
Research InstitutionHokkaido University (2017)
Kyushu University (2016)

Principal Investigator

LEE SANGIL  北海道大学, 工学研究院, 助教 (70738880)

Research Collaborator HIGUCHI Shigekazu  
OHASHI Michihiro  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords概日リズム / ヒト / 社会的時差ボケ / 栄養 / メラトニン / フィールド / 光 / 光環境 / 睡眠習慣 / 覚醒度 / フィールド実験 / 光の非視覚的作用 / 睡眠
Outline of Final Research Achievements

The aim of this study was to determine whether L-serine intake can promote circadian photoentrainment in real life. Thirty-five healthy university students (18 males and 17 females, 21.5 ± 2.2 yrs) participated in a four-week field study. During the experiment, we did not control participants’ sleep habits and social schedules. The participants were randomly divided into two groups (L-serine and placebo groups, double-blinded). In the L-serine group, a trend of phase advance was found after intake for 10 days, but it was not significantly greater than that of the placebo group. However, the L-serine group showed a relative circadian advance to sleep phase, whereas the placebo groups did not. In the data obtained from winter experiment, we found a greater circadian advance in the L-serine group compared with that in the placebo group.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2018 2017

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 実生活におけるL-Serine摂取が概日リズムの光同調に及ぼす影響2018

    • Author(s)
      大橋路弘,李相逸,松岡小百合,垂水千恵,安尾しのぶ,樋口重和
    • Organizer
      日本生理人類学会第77回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Promoting effect of L-Serine intake on circadian photoentrainment in humans2017

    • Author(s)
      Sang-il Lee, Kota Takeoka, Chie Tarumizu, Sayuri Matsuoka, Shinobu Yasuo, Shigekazu Higuchi
    • Organizer
      The Society for the Study of Human Biology (2017 SSHB - IAPA Joint Symposium)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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