Creation of new cancer treatment methods and analysis of cancer invasion and metastasis mechanism through delta-Np63 and microRNA
| Project/Area Number |
16K21246
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
Pathobiological dentistry/Dental radiology
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| Research Institution | Kagoshima University |
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Principal Investigator |
Goto Yuichi 鹿児島大学, 医歯学域歯学系, 助教 (00637902)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ΔNp63 / OSCC / miR205 / micro RNA / ZEB1 / EMT / ZEB2 / ΔNp63β / miRNA / miR-205 / 口腔扁平上皮癌 / 歯学 / 癌 |
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| Outline of Final Research Achievements |
Epithelial-mesenchymal transition (EMT) plays an important role in the process of development, recently it has been revealed that it also plays an important role in invasion and metastasis of cancer. We have shown that EMT is induced by suppressing the expression of ΔNp63β, a splicing variant of ΔNp63, in oral squamous cell carcinoma (OSCC). Furthermore, recent findings suggest that microRNA (miRNA) is involved in the molecular mechanism. We found that miR-205 plays an important role downstream of ΔNp63 and regulates its expression by targeting mesenchymal markers such as ZEB1 and ZEB2, which are associated with EMT.
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| Academic Significance and Societal Importance of the Research Achievements |
上皮系癌である口腔扁平上皮癌の浸潤・転移の分子メカニズムの一端を明らかにした。癌の転移は生命予後を左右する重要な事象で有るが、そのコントロールは出来ていない。浸潤・転移の分子メカニズムの全容が解明されることにより、その治療戦略が大きな転換点を迎える可能性があり、増加する口腔がんの治療戦略へ一石を投じることが出来る。
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Report
(5 results)
Research Products
(32 results)
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[Journal Article] Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma.2018
Author(s)
Maruse Y, Kawano S, Jinno T, Matsubara R, Goto Y, Kaneko N, Sakamoto T, Hashiguchi Y, Moriyama M, Toyoshima T, Kitamura R, Tanaka H, Oobu K, Kiyoshima T, Nakamura S.
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Journal Title
International Journal of Oral and Maxillofacial Surgery
Volume: －
Issue: 7
Pages: 836-845
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Tumor-suppressive roles of ΔNp63β-miR-205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2.2017
Author(s)
Yuma Hashiguchi, Shintaro Kawano, Yuichi Goto, Kaori Yasuda, Naoki Kaneko, Taiki Sakamoto, Ryota Matsubara, Teppei Jinno, Yasuyuki Maruse, Hideaki Tanaka, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Tamotsu Kiyoshima, Seiji Nakamura
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Journal Title
Journal of Cellular Physiology
Volume: －
Issue: 10
Pages: 6565-6577
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma.2017
Author(s)
Naoki Kaneko, Shintaro Kawano, Kaori Yasuda, Yuma Hashiguchi, Taiki Sakamoto, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Hideaki Tanaka, Ryoji Kitamura, Tamotsu Kiyoshima, Seiji Nakamura
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Journal Title
Oral Oncology
Volume: 75
Pages: 148-157
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition.2017
Author(s)
Taiki Sakamoto, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Naoki Kaneko, Yuma Hashiguchi, Taichi Hattori, Shoichi Tanaka, Ryoji Kitamura, Tamotsu Kiyoshima, Seiji Nakamura
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Journal Title
Oral Oncology
Volume: 69
Pages: 15-25
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 敗血症初期蘇生管理における急性血液浄化療法-循環・体液管理- 当施設における敗血症性ショック時の循環管理法2018
Author(s)
垣花 泰之, 安田 智嗣, 二木 貴弘, 大隣 貴仁, 古別府 裕明, 寺田 晋作, 宮本 昇太郎, 山下 翔太, 町田 千尋, 後藤 雄一, 上国料 千夏, 伊藤 隆史
Organizer
日本急性血液浄化学会
Related Report
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[Presentation] 敗血症性ショックにおける急性血液浄化療法の導入意義とは?2018
Author(s)
垣花 泰之, 安田 智嗣, 二木 貴弘, 大隣 貴仁, 古別府 裕明, 寺田 晋作, 宮本 昇太郎, 山下 翔太, 町田 千尋, 後藤 雄一, 上国料 千夏, 八島 望, 十時 崇彰, 谷口 賢二郎, 伊藤 隆史
Organizer
日本急性血液浄化学会
Related Report
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[Presentation] 舌エコーの画像所見による潜在的頸部リンパ節転移の予測2018
Author(s)
服部 多市, 川野 真太郎, 三上 友里恵, 筑井 徹, 河津 俊幸, 松原 良太, 後藤 雄一, 金子 直樹, 坂本 泰基, 橋口 有真, 神野 哲平, 丸瀬 靖之, 田中 翔一, 大部 一成, 中村 誠司
Organizer
日本口腔科学会
Related Report
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[Presentation] 口腔扁平上皮癌におけるkallikrein related peptidase 6の発現と機能に関する研究2017
Author(s)
金子直樹, 川野真太郎, 松原良太, 後藤雄一, 坂本泰基, 橋口有真, 神野哲平, 丸瀬靖之, 松村万由, 服部多市, 田中秀明, 大部一成, 中村誠司
Organizer
第35回 日本口腔腫瘍学会総会・学術大会
Place of Presentation
福岡国際会議場（福岡県福岡市）
Year and Date
2017-01-26
Related Report
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[Presentation] Involvement of Wnt5a-Ror2 signaling in aggressiveness of oral squamous cell carcinoma through ΔNp63β-mediated EMT2017
Author(s)
Taiki Sakamoto, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Naoki Kaneko, Yuma Hashiguchi, Taichi Hattori, Shoichi Tanaka, Kazunari Oobu, Seiji Nakamura
Organizer
KAOMS 2017
Related Report
Int'l Joint Research
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