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Analysis of insular output pathway for food anticipation

Research Project

Project/Area Number 16K21247
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
Neurophysiology / General neuroscience
Research InstitutionKagoshima University

Principal Investigator

KUSUMOTO Ikue  鹿児島大学, 医歯学域医学系, 助教 (80724757)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords島皮質 / 摂食行動 / 食欲 / 神経回路 / 摂食量 / c-fos / 摂食 / 予測 / 報酬予測
Outline of Final Research Achievements

Food deprivation or natural hunger produce a drive to seek and consume food. Cortical regulation of this motivation remains poorly understood. We used optogenetics to characterize functional importance of anatomical connection to and/or from insular cortex in mice. Several hypothalamic areas are known for its function to modulate eating behavior. Among all those areas Orexin neurons which are mainly located in lateral part of the hypothalamus has been implicated in not only food intake but also motivational aspect of eating behavior. We thus examined appetitive effect of orexin input to the insular cortex.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Presentation (4 results)

  • [Presentation] Optogenetic stimulation of orexin neurons elicits feeding behavior in mice2017

    • Author(s)
      Ran Yamaguchi, Tomoyuki Kuwaki, Ikue Kusumoto-Yoshida
    • Organizer
      The 94th Annual Meeting of the Physiology Society of Japan
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] マウスにおける島皮質を介したオレキシン摂食促進機構2017

    • Author(s)
      楠本-吉田郁恵 山口蘭 桑木共之
    • Organizer
      第2回食欲・食嗜好の分子・神経基盤研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] オレキシンによる摂食促進作用に関係する神経回路の機能的解析2017

    • Author(s)
      楠本-吉田郁恵 山口蘭 桑木共之
    • Organizer
      Neuroscience2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウスの摂食行動に対するオレキシン神経光刺激の効果2016

    • Author(s)
      山口蘭、桑木共之、楠本(吉田)郁恵
    • Organizer
      第67回西日本生理学会
    • Place of Presentation
      レインボー桜島(鹿児島県・鹿児島市)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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