• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanism of the ILC2 activation in bronchial asthma regulated by deltaNp63-related epimmunome

Research Project

Project/Area Number 16K21249
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Respiratory organ internal medicine
Research InstitutionSapporo Medical University

Principal Investigator

KUBO Terufumi  札幌医科大学, 医学部, 助教 (90580019)

Research Collaborator TSUJIWAKI Mitsuhiro  
HIROHASHI Yoshihiko  
TSUKAHARA Tomohide  
KANASEKI Takayuki  
NAKATSUGAWA Munehide  
HASEGAWA Tadashi  
TORIGOE Toshihiko  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords気管支喘息 / 気管支上皮細胞 / deltaNp63 / プロテアーゼ / サイトカイン / プロテアーゼ阻害因子 / 気管支上皮 / ΔNp63 / アポトーシス / p63 / アレルギー・ぜんそく / 病理学 / 免疫学
Outline of Final Research Achievements

ΔNp63-positive basal epithelial cells were covered with differentiated ΔNp63-negative cells in healthy bronchial tissue; however, ΔNp63-positive cells were directly exposed to the bronchial lumen due to severe epithelial shedding in the asthmatic airway. ΔNp63 regulated bronchial apoptosis in response to Toll-like receptor 3 stimulation. Expression of ΔNp63 was modulated by stimulation with the certain type of protease signal. On the other hand, ΔNp63 controlled the transcriptional expression and protein release of some epithelium-derived proinflammatory cytokines and endogenous protease inhibitors.

Academic Significance and Societal Importance of the Research Achievements

我々の検討によって気管支上皮細胞が発現するdeltaNp63はウイルス感染に対する気管支上皮細胞の反応を制御しうることが示された。また、deltaNp63の発現を制御するプロテアーゼはハウスダストに含まれるダニに含まれている。つまり、気管支上皮細胞の振る舞いを制御するdeltaNp63は、気管支喘息の増悪の主たる原因となるウイルス感染とハウスダスト曝露を結びつける因子となっている可能性が示唆された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Differential bronchial epithelial response regulated by ΔNp63: a functional understanding of the epithelial shedding found in asthma2018

    • Author(s)
      Kubo Terufumi、Tsujiwaki Mitsuhiro、Hirohashi Yoshihiko、Tsukahara Tomohide、Kanaseki Takayuki、Nakatsugawa Munehide、Hasegawa Tadashi、Torigoe Toshihiko
    • Journal Title

      Laboratory Investigation

      Volume: 99 Issue: 2 Pages: 158-168

    • DOI

      10.1038/s41374-018-0132-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Differential bronchial epithelial response regulated by deltaNp63 : a potential mechanism explaining chronicity of asthma2017

    • Author(s)
      Terufumi Kubo
    • Organizer
      第46回 日本免疫学会
    • Related Report
      2017 Research-status Report
  • [Presentation] ΔNp63 regulate bronchial epithelial response: a potential mechanism of chronic airway inflammation2016

    • Author(s)
      Terufumi Kubo
    • Organizer
      第45回 日本免疫学会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi