Hypoxia imaging using new MRI technology
| Project/Area Number |
16K21279
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
Medical Physics and Radiological Technology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Murai Taro 名古屋市立大学, 医薬学総合研究院(医学), 助教 (00747602)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 低酸素イメージング / 低酸素 / 放射線抵抗性 / 低酸素細胞 / 放射線治療 / MRI / 低酸素環境 / 放射線 / 癌 |
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| Outline of Final Research Achievements |
In this study, we tried to utilize H-MRI for hypoxic area detection in murine tumors. The hypoxic area was less than 15 mmHg of oxygen partial pressure. For the low partial pressure induces resistance to irradiation. Despite of many trials, we found that some hurdles remained. One of those was tumor size. Tumors transplanted in mice were too small to detect in our MRI. Therefore, we changed strategy to overcome radio-resistance in radiotherapy in clinical practice. We analyzed some radiosensitizers to reduce hypoxic effects on tumors in biological and clinical settings. This grant was used for these studies.
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| Academic Significance and Societal Importance of the Research Achievements |
いくつかの条件でトライアルを行ったが、本研究の目的である通常の水素スピンを用いたMRIでは放射線治療で問題になる15mmHgレベルの低酸素環境を測定することは難しかった。これはマウスに移植した腫瘍では病変が小さくボクセルサイズの関係から検出が難しかったことも理由として考えられる。しかし、本検討の最終目的は、臨床における放射線抵抗性の克服である。そこで、本助成金を用い、いくつかの放射線増感剤（局注型放射線増感剤やHSP阻害剤）の生物学的検証を行った。さらに局注型増感剤を用いた臨床試験についても論文化した。MRIを用いた研究としては、拡散強調画像を用いた骨悪性腫瘍の検討についても論文化した。
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Organ-preserving approach via radiotherapy for small cell carcinoma of the bladder: an analysis based on the Japanese Radiation Oncology Study Group (JROSG) survey.2019
Author(s)
Akamatsu H, Nakamura K, Ebara T, Inaba K, Itasaka S, Jingu K, Kosaka Y, Murai T, Nagata K, Soejima T, Takahashi S, Toyoda T, Toyoshima S, Nemoto K, Akimoto T.
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Journal Title
J Radiat Res.
Volume: 60
Issue: 4
Pages: 509-516
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Biological effects of hydrogen peroxide administered intratumorally with or without irradiation in murine tumors.2017
Author(s)
Takaoka T, Shibamoto Y, Matsuo M, Sugie C, Murai T, Ogawa Y, Miyakawa A, Manabe Y, Kondo T, Nakajima K, Okazaki D, Tsuchiya T.
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Journal Title
Cancer Sci.
Volume: 08(9)
Issue: 9
Pages: 1787-1792
DOI
Related Report
Peer Reviewed / Open Access
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