| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Nicotinic acetylcholine receptor exhibits at least three functional states. The structure of nicotinic acetylcholine receptor is switched among the three states. In this study rotation of extracellular domain was detected in presence of ligand by Diffracted X-ray tracking using live mammalian cell culture, which is related to the transition of functional states. The rotation was stopped by a toxin, which inhibits opening of the receptor channel. It was considered that the rotation of extracellular domain including ligand binding site is correlated to the open-close mechanisms of the receptor channel.
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