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Development of induced production method for dormant fungal secondary metabolites with a combination of chemical epigenetics and several culture conditions

Research Project

Project/Area Number 16K21310
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomolecular chemistry
Natural medicines
Research InstitutionTohoku Medical and Pharmaceutical University

Principal Investigator

YAMAZAKI Hiroyuki  東北医科薬科大学, 薬学部, 講師 (70525344)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords休眠生合成遺伝子 / 二次代謝産物 / 新規活性物質 / 海洋微生物 / 糸状菌 / 放線菌 / 誘導生産 / 新規生物活性物質 / 特殊培養条件 / 海洋糸状菌 / 海洋放線菌 / ケミカルエピジェネティクス / 共培養 / 植物内生糸状菌
Outline of Final Research Achievements

We have investigated several culture conditions in order to utilize the dormant ability to produce various microbial secondary metabolites. During our efforts, further purification on the culture broth of Trichoderma sp. TPU199 with NaI-supplemented medium, which has been found as a producer of halogenated metabolites by sodium halides-containing culture, gave two new metabolites. These new compounds would be generated from I derivatives as intermediates, suggesting that this simple fermentation method in this study will expand the diversity of secondary metabolites. Moreover, seventeen new metabolites were isolated from the culture broths of nine fungal and one actinomycete strains (including TPU199 strain) in the course of this study.

Academic Significance and Societal Importance of the Research Achievements

糸状菌や放線菌に代表される微生物資源は数多くの医薬シード (抗生物質の種) を提供したきたが, このような探索研究が積み重ねられるにつれて有用な抗生物質を見出すことが年々難しくなってきた. 本研究では, これまでに利用されていない眠った状態にある二次代謝産物生合成遺伝子に着目し, 微生物遺伝子資源の新しい活用方法の提供に取り組んできた. 休眠状態を解除する新しい手法が多くの微生物資源に応用できれば, 既存資源の再開拓と新たな有用物質の発見, そして有効な抗生物質への開発が期待される.

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (70 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (31 results) (of which Int'l Joint Research: 20 results,  Peer Reviewed: 31 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (32 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (4 results)

  • [Int'l Joint Research] Sam Ratulangi University/University of Pembangunan Indonesia/Christian University of Indonesia(インドネシア)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Sam Ratulangi University/University of Pembangunan Indonesia(インドネシア)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Sam Ratulangi University(インドネシア)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Epipolythiodiketopiperazine and trichothecene derivatives from the NaI-containing fermentation of marine-derived Trichoderma cf. brevicompactum2020

    • Author(s)
      Yamazaki Hiroyuki、Takahashi Ohgi、Kirikoshi Ryota、Yagi Akiho、Ogasawara Teruki、Bunya Yuki、Rotinsulu Henki、Uchida Ryuji、Namikoshi Michio
    • Journal Title

      The Journal of Antibiotics

      Volume: 73 Issue: 8 Pages: 559-567

    • DOI

      10.1038/s41429-020-0314-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Search for Protein Tyrosine Phosphatase 1B Inhibitors from Marine Organisms and Induced Production of New Fungal Metabolites by Modulating Culture Methods2019

    • Author(s)
      Yamazaki Hiroyuki
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 139 Issue: 5 Pages: 663-672

    • DOI

      10.1248/yakushi.18-00221

    • NAID

      130007641022

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2019-05-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of an α-pyrone metabolite and microbial transformation of isoflavones by an Indonesian Streptomyces sp.2019

    • Author(s)
      Wewengkang Defny S.、Yamazaki Hiroyuki、Takahashi Moe、Togashi Toshiki、Rotinsulu Henki、Sumilat Deiske A.、Namikoshi Michio
    • Journal Title

      Journal of Asian Natural Products Research

      Volume: - Issue: 8 Pages: 1-8

    • DOI

      10.1080/10286020.2019.1635588

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inhibition of neutral lipid synthesis by avarols from a marine sponge.2019

    • Author(s)
      Ohshiro T, Kobayashi K, Suzuki A, Yamazaki H, Uchida R, Namikoshi M, Tomoda H.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 29 Issue: 16 Pages: 2283-2285

    • DOI

      10.1016/j.bmcl.2019.06.026

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of interleukin-8 production in interleukin-1 stimulated human monocytic THP-1 cells by N,N didesmethylgrossularine-1 obtained from an Ascidian Polycarpa aurata collected in North Sulawesi2019

    • Author(s)
      Sumilat Deiske A.、Oda Taiko、Wewengkang Defny S.、Namikoshi Michio、Yamazaki Hiroyuki
    • Journal Title

      IOP Conference Series: Materials Science and Engineering

      Volume: 567 Issue: 1 Pages: 012021-012021

    • DOI

      10.1088/1757-899x/567/1/012021

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Absolute Structures of Wedelolide Derivatives and Structure–Activity Relationships of Protein Tyrosine Phosphatase 1B Inhibitory <i>ent</i>-Kaurene Diterpenes from Aerial Parts of <i>Wedelia</i> spp. Collected in Indonesia and Japan2018

    • Author(s)
      Abdjul Delfly Booby、Yamazaki Hiroyuki、Kanno Syu-ichi、Kirikoshi Ryota、Tomizawa Ayako、Takahashi Ohgi、Maarisit Wilmar、Losung Fitje、Rotinsulu Henki、Wewengkang Defny Silvia、Sumilat Deiske Adeliene、Kapojos Magie Melanie、Namikoshi Michio
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 66 Issue: 6 Pages: 682-687

    • DOI

      10.1248/cpb.c18-00117

    • NAID

      130007382328

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2018-06-01
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Halogenated cladosporols produced by the sodium halide-supplemented fermentation of the plant-associated fungus Cladosporium sp. TMPU16212018

    • Author(s)
      Yamazaki Hiroyuki、Yagi Akiho、Akaishi Masanari、Kirikoshi Ryota、Takahashi Ohgi、Abe Tatsuki、Chiba Satomi、Takahashi Kenta、Iwakura Natsuki、Namikoshi Michio、Uchida Ryuji
    • Journal Title

      Tetrahedron Letters

      Volume: 59 Issue: 20 Pages: 1913-1915

    • DOI

      10.1016/j.tetlet.2018.03.082

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bioactivity of extracts from ascidians collected in North Sulawesi as seeds of marine-derived drugs2018

    • Author(s)
      Sumilat Deiske A.、Wewengkang Defny S.、Rotinsulu Henki、Yamazaki Hiroyuki、Oda Taiko、Ukai Kazuyo、Namikoshi Michio
    • Journal Title

      AACL. Bioflux

      Volume: 11 Pages: 516-524

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp.2018

    • Author(s)
      Kapojos MM, Abdjul DB, Yamazaki H, Ohshiro T, Rotinsulu H, Wewengkang DS, Sumilat DA, Tomoda H, Namikoshi M, Uchida R.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 28 Issue: 10 Pages: 1911-1914

    • DOI

      10.1016/j.bmcl.2018.03.077

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cladosporamide A, a new protein tyrosine phosphatase 1B inhibitor, produced by an Indonesian marine sponge-derived Cladosporium sp.2018

    • Author(s)
      Rotinsulu Henki、Yamazaki Hiroyuki、Sugai Shino、Iwakura Natsuki、Wewengkang Defny S.、Sumilat Deiske A.、Namikoshi Michio
    • Journal Title

      Journal of Natural Medicines

      Volume: 72 Issue: 3 Pages: 779-783

    • DOI

      10.1007/s11418-018-1193-y

    • NAID

      40021618028

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A new protein tyrosine phosphatase 1B inhibitory α-pyrone derivative from the Okinawan plant-associated Aspergillus sp. TMPU16232018

    • Author(s)
      Yamazaki Hiroyuki、Takahashi Kenta、Iwakura Natsuki、Abe Tatsuki、Akaishi Masanari、Chiba Satomi、Namikoshi Michio、Uchida Ryuji
    • Journal Title

      The Journal of Antibiotics

      Volume: 印刷中 Issue: 8 Pages: 745-748

    • DOI

      10.1038/s41429-018-0054-y

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-mycobacterial haliclonadiamine alkaloids from the Okinawan marine sponge Haliclona sp. collected at Iriomote Island2018

    • Author(s)
      Abdjul Delfly B.、Yagi Akiho、Yamazaki Hiroyuki、Kirikoshi Ryota、Takahashi Ohgi、Namikoshi Michio、Uchida Ryuji
    • Journal Title

      Phytochemistry Letters

      Volume: 26 Pages: 130-133

    • DOI

      10.1016/j.phytol.2018.05.028

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protein tyrosine phosphatase 1B inhibitory polybromobiphenyl ethers and monocyclofarnesol-type sesquiterpenes from the Indonesian marine sponge Lamellodysidea cf. herbacea2018

    • Author(s)
      Kapojos Magie M.、Abdjul Delfly B.、Yamazaki Hiroyuki、Kirikoshi Ryota、Takahashi Ohgi、Rotinsulu Henki、Wewengkang Defny S.、Sumilat Deiske A.、Ukai Kazuyo、Namikoshi Michio
    • Journal Title

      Phytochemistry Letters

      Volume: 24 Pages: 10-14

    • DOI

      10.1016/j.phytol.2017.11.016

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Protein tyrosine phosphatase 1B inhibitory components and a new unique N-alkylamide derivative with an endoperoxide bridge from aerial parts of Indonesian Spilanthes paniculata2018

    • Author(s)
      Abdjul Delfly B.、Yamazaki Hiroyuki、Maarisit Wilmar、Kirikoshi Ryota、Takahashi Ohgi、Losung Fitje、Kapojos Magie M.、Namikoshi Michio
    • Journal Title

      Phytochemistry Letters

      Volume: 24 Pages: 71-74

    • DOI

      10.1016/j.phytol.2018.01.013

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A bromopyrrole-containing diterpene alkaloid from the Okinawan marine sponge Agelas nakamurai activates the insulin pathway in Huh-7 human hepatoma cells by inhibiting protein tyrosine phosphatase 1B2017

    • Author(s)
      Yamazaki Hiroyuki、Kanno Syu-ichi、Abdjul Delfly B.、Namikoshi Michio
    • Journal Title

      Bioorganic & medicinal chemistry letters

      Volume: 27 Issue: 10 Pages: 2207-2209

    • DOI

      10.1016/j.bmcl.2017.03.033

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Eudesmanolide sesquiterpenes and protein tyrosine phosphatase 1B inhibitory ent-kaurene diterpenes from aerial parts of Indonesian Wedelia prostata2017

    • Author(s)
      Abdjul Delfly B.、Yamazaki Hiroyuki、Maarisit Wilmar、Losung Fitje、Rotinsulu Henki、Wewengkang Defny S.、Sumilat Deiske A.、Namikoshi Michio
    • Journal Title

      Phytochemistry Letters

      Volume: 20 Pages: 191-195

    • DOI

      10.1016/j.phytol.2017.04.018

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Anti-mycobacterial alkaloids, cyclic 3-alkyl pyridinium dimers, from the Indonesian marine sponge Haliclona sp.2017

    • Author(s)
      Maarisit Wilmar、Abdjul Delfly B.、Yamazaki Hiroyuki、Kato Hajime、Rotinsulu Henki、Wewengkang Defny S.、Sumilat Deiske A.、Kapojos Magie M.、Ukai Kazuyo、Namikoshi Michio
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 27 Issue: 15 Pages: 3503-3506

    • DOI

      10.1016/j.bmcl.2017.05.067

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An anti-mycobacterial bisfunctionalized sphingolipid and new bromopyrrole alkaloid from the Indonesian marine sponge Agelas sp.2017

    • Author(s)
      Abdjul Delfly B.、Yamazaki Hiroyuki、Kanno Syu-ichi、Tomizawa Ayako、Rotinsulu Henki、Wewengkang Defny S.、Sumilat Deiske A.、Ukai Kazuyo、Kapojos Magie M.、Namikoshi Michio
    • Journal Title

      Journal of Natural Medicines

      Volume: 71 Issue: 3 Pages: 531-536

    • DOI

      10.1007/s11418-017-1085-6

    • NAID

      40021218301

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A New Pyranonaphtoquinone Derivative, 4-Oxo-rhinacanthin A, from Roots of Indonesian <i>Rhinacanthus nasutus</i>2017

    • Author(s)
      Maarisit Wilmar、Yamazaki Hiroyuki、Abdjul Delfly Booby、Takahashi Ohgi、Kirikoshi Ryota、Namikoshi Michio
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 65 Issue: 6 Pages: 586-588

    • DOI

      10.1248/cpb.c17-00074

    • NAID

      130005686030

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A new biphenyl ether derivative produced by Indonesian ascidian-derived Penicillium albobiverticillium2017

    • Author(s)
      Sumilat Deiske A.、Yamazaki Hiroyuki、Endo Kotaro、Rotinsulu Henki、Wewengkang Defny S.、Ukai Kazuyo、Namikoshi Michio
    • Journal Title

      Journal of Natural Medicines

      Volume: 71 Issue: 4 Pages: 776-779

    • DOI

      10.1007/s11418-017-1094-5

    • NAID

      40021338063

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A 2,4′-linked tetrahydroxanthone dimer with protein tyrosine phosphatase 1B inhibitory activity from the Okinawan freshwater Aspergillus sp.2017

    • Author(s)
      Rotinsulu Henki、Yamazaki Hiroyuki、Miura Tomohito、Chiba Satomi、Wewengkang Defny S、Sumilat Deiske A、Namikoshi Michio
    • Journal Title

      The Journal of Antibiotics

      Volume: 70 Issue: 9 Pages: 967-969

    • DOI

      10.1038/ja.2017.72

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Oleanane triterpenes with protein tyrosine phosphatase 1B inhibitory activity from aerial parts of Lantana camara collected in Indonesia and Japan2017

    • Author(s)
      Abdjul Delfly B.、Yamazaki Hiroyuki、Maarisit Wilmar、Rotinsulu Henki、Wewengkang Defny S.、Sumilat Deiske A.、Kapojos Magie M.、Losung Fitje、Ukai Kazuyo、Namikoshi Michio
    • Journal Title

      Phytochemistry

      Volume: 144 Pages: 106-112

    • DOI

      10.1016/j.phytochem.2017.08.020

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Protein tyrosine phosphatase 1B inhibitory properties of seco-cucurbitane triterpenes obtained from fruiting bodies of Russula lepida.2017

    • Author(s)
      Maarisit, W.; Yamazaki, H.; Kanno, S.; Tomizawa, A.; Lee, J.-S.; Namikoshi, M.
    • Journal Title

      J. Nat. Med.

      Volume: 71 Issue: 1 Pages: 334-337

    • DOI

      10.1007/s11418-016-1061-6

    • NAID

      40021062945

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A tetramic acid derivative with protein tyrosine phosphatase 1B inhibitory activity and a new nortriterpene glycoside from the Indonesian marine sponge Petrosia sp.2017

    • Author(s)
      Maarisit, W.; Yamazaki, H.; Kanno, S.; Tomizawa, A.; Rotinsulu, H.; Wewengkang, D. S.; Sumilat, D. A.; Ukai, K.; Kapojos, M. M.; Namikoshi, M.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 4 Pages: 999-1002

    • DOI

      10.1016/j.bmcl.2016.12.077

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.2017

    • Author(s)
      Abdjul, D. B.; Yamazaki, H.; Kanno, S.; Wewengkang, D. S.; Rotinsulu, H.; Sumilat, D. A.; Ukai, K.; Namikoshi, M.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 5 Pages: 1159-1161

    • DOI

      10.1016/j.bmcl.2017.01.071

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Biphenyl ether derivatives with protein tyrosine phosphatase 1B inhibitory activity from a freshwater fungus Phoma sp.2017

    • Author(s)
      Sumilat, D.A.; Yamazaki, H.; Kanno, S.; Saito, R.; Watanabe, Y.; Namikoshi, M.
    • Journal Title

      J. Antibiot.

      Volume: 70 Issue: 3 Pages: 331-333

    • DOI

      10.1038/ja.2016.147

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lissoclibadin 1, a polysulfur aromatic alkaloid obtained from the Indonesian ascidian Lissoclinum cf. badium, induces caspase-dependent apoptosis in human colon cancer cells and suppresses tumor growth in nude mice.2017

    • Author(s)
      Tatsuta, T.; Hosono, M.; Namikoshi, M.; Rotinsulu, H.; Wewengkang, D.S.; Sumilat, D.A.; Yamazaki, H.
    • Journal Title

      J. Nat. Prod.

      Volume: 80 Issue: 2 Pages: 499-502

    • DOI

      10.1021/acs.jnatprod.6b01051

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Halichlonadiamine derivatives and 6-epi-monanchorin from the marine sponge Halichondria panicea collected at Iriomote Island.2016

    • Author(s)
      Abdjul, D.B.; Yamazaki, H.; Kanno, S.; Takahashi, O.; Kirikoshi, R.; Ukai, K.; Namikoshi, M.
    • Journal Title

      J. Nat. Prod.

      Volume: 79 Issue: 4 Pages: 1149-1154

    • DOI

      10.1021/acs.jnatprod.6b00095

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isopetrosynol, a New Protein Tyrosine Phosphatase 1B Inhibitor, from the Marine Sponge <i>Halichondria</i> cf. <i>panicea</i> Collected at Iriomote Island2016

    • Author(s)
      Abdjul, D.B.; Yamazaki, H.; Takahashi, O.; Kirikoshi, R.; Ukai, K.; Namikoshi, M.
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 7 Pages: 733-736

    • DOI

      10.1248/cpb.c16-00061

    • NAID

      130005160060

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sesquiterpene hydroquinones with protein tyrosine phosphatase 1B inhibitory activities from a Dysidea sp. marine sponge collected in Okinawa.2016

    • Author(s)
      Abdjul, D.B.; Yamazaki, H.; Takahashi, O.; Kirikoshi, R.; Ukai, K.; Namikoshi, M.
    • Journal Title

      J. Nat. Prod.

      Volume: 79 Issue: 7 Pages: 1842-1847

    • DOI

      10.1021/acs.jnatprod.6b00367

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Induced production of a new modified dipeptide with a disufide bridge by the long-term fermentation of a marine-derived Trichoderma cf. brevicompactum.2016

    • Author(s)
      Yamazaki, H.; Rotinsulu, H.; Takahashi, O.; Kirikoshi, R.; Namikohsi, M.
    • Journal Title

      Tetrahedron Lett.

      Volume: 57 Issue: 51 Pages: 5764-5767

    • DOI

      10.1016/j.tetlet.2016.11.028

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 宮城県産Petasites japonicusより得られたセスキテルペン類のprotein tyrosine phosphatase 1B阻害活性2020

    • Author(s)
      山﨑寛之, 柘植勇人, 千田貴大, 石井望美, 大森かりん, 高橋泰大, 八木澤裕太, 遠藤 伶, 内田龍児
    • Organizer
      日本薬学会第141年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] インドネシア産食用植物に由来するprotein tyrosine phosphatase 1B阻害物質の探索2020

    • Author(s)
      山﨑寛之, Magie M. Kapojos, Delfly B. Abdjul, 千田貴大, 八木瑛穂, 内田龍児
    • Organizer
      日本薬学会第141年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 放線菌TMPU-A0287株が生産する抗真菌活性物質に関する研究2020

    • Author(s)
      山口優雅, 八木瑛穂, 山﨑寛之, 内田龍児
    • Organizer
      日本薬学会第141年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] イントドネシアにおける海洋天然資源の調査研究および微生物による含ハロケゲン二次代謝産物の効率的生産2019

    • Author(s)
      山﨑寛之
    • Organizer
      日本生薬学会 第66回年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 生活習慣病の予防・改善を目指したランタナ由来oleanane型トリテルぺンに関する研究2019

    • Author(s)
      山﨑寛之, 大城太一, Delfly B. Abdjul, 関 怜子, 大手聡, 供田洋, 浪越通夫, 内田龍児
    • Organizer
      日本生薬学会 第66回年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] フキノトウ (Petasites japonicus) から単離されたPTP1B阻害物質2019

    • Author(s)
      山﨑寛之, 石井望美, 遠藤 伶, 大森かりん, 高橋泰大, 八木澤裕太, 内田 龍児
    • Organizer
      第58回 日本薬学会東北支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 海洋糸状菌Trichoderma cf. brevicompactum TPU199株が生産する新規trichothecene類の抗真菌活性2019

    • Author(s)
      八木瑛穂 , 山﨑寛之, 斉藤杏里, 浪越通夫, 内田龍児
    • Organizer
      第58回 日本薬学会東北支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 放線菌TMPU-A0004株が生産する抗真菌活性物質2019

    • Author(s)
      山口優雅, 千葉まれの, 山﨑寛之, 内田龍児
    • Organizer
      第58回 日本薬学会東北支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Screening for PTP1B inhibitors from Indonesian edible plants2019

    • Author(s)
      Magie M. Kapojos, Delfly B. Abdjul, Hiroyuki Yamazaki, Akiho Yagi, Ryuji Uchida
    • Organizer
      第58回 日本薬学会東北支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] カイコ Mycobacterium avium complex 症モデルの構築と天然化合物ライブラリーの評価2019

    • Author(s)
      八木瑛穂, 山﨑寛之, 内田龍児
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Research-status Report
  • [Presentation] SOAT2選択的阻害活性を有するoleanane型トリテルペン化合物類に関する研究2019

    • Author(s)
      大城太一, 関 怜子, 山﨑寛之, 大手聡, Delfly B. Abdjul, 内田龍児, 浪越通夫, 供田 洋
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Research-status Report
  • [Presentation] インドネシア産海綿由来の新規骨芽細胞分化阻害物質に関する研究2019

    • Author(s)
      大手聡, 山﨑寛之, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, 内田龍児, 浪越通夫, 片桐岳信, 供田 洋
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Anti-mycobacterial activity from the marine sponge Haliclona sp.2018

    • Author(s)
      Wilmar Maarisit, Hiroyuki Yamazaki, Kazuyo Ukai, Michio Namikoshi
    • Organizer
      1st International Seminar on Pharmaceutical 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Oleanane型トリテルぺン化合物類のSOAT2阻害活性2018

    • Author(s)
      大城太一, 関 怜子, 山﨑寛之, Delfly B. Abdjul, 内田龍児, 浪越通夫, 供田 洋
    • Organizer
      第57回日本薬学会東北支部大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Isolation and characterization of small molecule inhibitors of BMP induced osteoblastic differentiation from the Indonesian marine sponge2018

    • Author(s)
      Satoshi Ohte, Hiroyuki Yamazaki, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Ryuji Uchida, Michio Namikoshi, Takenobu Katagiri, Hiroshi Tomoda
    • Organizer
      12th International BMP conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] インドネシアおよび八重山諸島産Lantana camaraより得られたoleanane型トリテルペンの構造とprotein tyrosine phosphatase 1B阻害活性2018

    • Author(s)
      山﨑寛之, Delfly B. Abdjul, Wilmar Maarisit, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Magie M. Kapojos, Fitje Losung, 浪越通夫
    • Organizer
      日本薬学会 第138年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 植物内生糸状菌Cladosporium sp. TMPU1621株が生産する抗生物質およびハロゲン化物塩を用いた新規類縁体の生産誘導2018

    • Author(s)
      八木瑛穂, 赤石将成, 桐越亮太, 高橋央宜, 阿部 樹, 髙橋健太, 千葉聡美, 山﨑寛之, 内田龍児
    • Organizer
      日本薬学会 第138年会
    • Related Report
      2017 Research-status Report
  • [Presentation] パラオ産海洋糸状菌Trichoderma cf. brevicompactum TPU199株のNaI添加培養による新規二次代謝産物の生産誘導2017

    • Author(s)
      山﨑 寛之, 高橋 央宜, 桐越 亮太, 文屋 友希, 浪越 通夫
    • Organizer
      日本薬学会 第137回年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] インドネシア産海洋糸状菌Cladosporium sp. TPU1507株が生産するprotein tyrosine phosphatase 1B阻害剤2017

    • Author(s)
      山﨑 寛之, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, 菅井 紫乃, 鵜飼 和代, 浪越 通夫
    • Organizer
      日本薬学会 第137回年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] An anti-mycobacterial sphingolipid and a new bromopyrrol alkaloid from an unidentified Indonesian marine sponge2017

    • Author(s)
      Delfly B. Abdjul, Hiroyuki Yamazaki, Syu-ichi Kanno, Ayako Tomizawa, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Kazuyo Ukai, Magie M. Kapojos, Michio Namikoshi
    • Organizer
      日本薬学会 第137回年会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Structures and biological activities of alkyl pyridinium alkaloids from an unidentified Indonesian marine sponge2017

    • Author(s)
      Wilmar Maarisit, Delfly B. Abdjul, Hiroyuki Yamazaki, Hajime Kato, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Kazuyo Ukai, Magie M. Kapojos, Michio Namikoshi
    • Organizer
      日本薬学会 第137回年会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 西表島産海綿Haliclona sp.より得られた新規halichondriamine類の構造と生物活性2017

    • Author(s)
      山﨑寛之, Delfly B. Abdjul, 桐越亮太, 八木瑛穂, 高橋央宜, 内田龍児, 浪越通夫
    • Organizer
      日本生薬学会 第64回年会
    • Related Report
      2017 Research-status Report
  • [Presentation] インドネシア産Wedelia prostata由来新規セスキテルぺンの構造およびent-kaurene型ジテルぺンのprotein tyrosine phosphatase 1B阻害活性2017

    • Author(s)
      山﨑寛之, Delfly B. Abdjul, 菅野秀一, 桐越亮太, 高橋央宜, 浪越通夫
    • Organizer
      第59回 天然有機化合物討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] 石垣島由来植物内生糸状菌Aspergillus sp. TMPU1623株が生産する新規protein tyrosine phosphatase 1B阻害剤2017

    • Author(s)
      山﨑寛之, 高橋健太, 岩倉夏樹, 赤石将成, 阿部 樹, 千葉聡美, 浪越通夫, 内田龍児
    • Organizer
      第56回 日本薬学会東北支部大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 植物内生糸状菌Cladosporium sp. TMPU1621株が生産する抗生物質に関する研究2017

    • Author(s)
      八木瑛穂, 赤石将成, 阿部 樹, 髙橋健太, 千葉聡美, 山﨑寛之, 内田龍児
    • Organizer
      第56回 日本薬学会東北支部大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 海洋生物由来protein tyrosine phosphatase 1B阻害剤に関する研究および培養法検討による新規糸状菌二次代謝産物の誘導生産2017

    • Author(s)
      山﨑寛之
    • Organizer
      第39回 東北薬学セミナー
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Sesquiterpene hydroquinones with protein tyrosine phosphatase 1B inhibitory activities from a marine sponge Dysidea sp. collected at Iriomote Island2016

    • Author(s)
      Delfly B. Abdjul, Hiroyuki Yamazaki, Ohgi Takahashi, Ryota Kirikoshi, Kazuyo Ukai, Michio Namikoshi
    • Organizer
      第21回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      千葉大学(千葉県千葉市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 西表島産海洋生物より得られたprotein tyrosine phosphatase 1B阻害活性物質2016

    • Author(s)
      山﨑 寛之, Delfly B. Abdjul, 菅野 秀一, 鵜飼 和代, 浪越 通夫
    • Organizer
      第21回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      千葉大学(千葉県千葉市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 青森県早掛沼由来Phoma sp. TPU1222株が生産する新規protein tyrosine phosphatase 1B阻害剤に関する研究2016

    • Author(s)
      山﨑 寛之, 菅野 秀一, 齊藤 亮, 渡辺 裕太, 浪越通夫
    • Organizer
      第55回 日本薬学会東北支部大会
    • Place of Presentation
      奥羽大学(福島県郡山市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] New sesquiterpene lactones from the aerial parts of Indonesian Wedelia prostata2016

    • Author(s)
      Delfly B. Abdjul, Hiroyuki Yamazaki, Syu-ichi Kanno, Wilmar Maarisit, Fitje Losung, Henki Rotinsulua, Defny S. Wewengkanga, Deiske A. Sumilat, Michio Namikoshi
    • Organizer
      第55回 日本薬学会東北支部大会
    • Place of Presentation
      奥羽大学(福島県郡山市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Search for protein tyrosine phosphatase 1B inhibitors from an Indonesian marine sponge Petrosia sp.2016

    • Author(s)
      Wilmar Maarisit, Hiroyuki Yamazaki, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Kazuyo Ukai, Michio Namikoshi
    • Organizer
      第55回 日本薬学会東北支部大会
    • Place of Presentation
      奥羽大学(福島県郡山市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Structures and PTP1B inhibitory activities of triterpenes and sesquiterpenes obtained from Russula lepida2016

    • Author(s)
      Wilmar Maarisit, Jong-Soo Lee, Delfly B. Abdjul, Hiroyuki Yamazaki, Syu-ichi Kanno, Ohgi Takahashi, Ryota Kirikoshi, Michio Namikoshi
    • Organizer
      第58回 天然有機化合物討論会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Research-status Report
  • [Remarks] 東北医科薬科大学 薬学部 天然物化学教室 ホームページ

    • URL

      http://www.tohoku-mpu.ac.jp/laboratory/tennen/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東北医科薬科大学 薬学部 天然物化学教室 ホームページ

    • URL

      http://www.tohoku-mpu.ac.jp/laboratory/tennen/index.html

    • Related Report
      2018 Research-status Report
  • [Remarks] 東北医科薬科大学 薬学部 天然物化学教室 ホームページ

    • URL

      http://www.tohoku-mpu.ac.jp/laboratory/tennen/site/index.html

    • Related Report
      2017 Research-status Report
  • [Remarks] 東北医科薬科大学 薬学部 天然物化学教室

    • URL

      http://www.tohoku-mpu.ac.jp/laboratory/tennen/site/index.html

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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