| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In this study, examined the effect of Syk inhibitor on cell fusion on osteoclasts responsible for bone resorption in bone metabolism. As a result, it was found that cell fusion was promoted in the late stage of differentiation of Osteoclast precursor cell-like cells ‘‘RAW264.7 cells’’ . Such an effect was widely discernibled in Syk inhibitors. However, the results of real-time PCR indicated that osteoclast-related factors were not affected, and that cell fusion was due to changes in the structure of the sealing zone.
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