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Elucidation of the onset mechanism of the fatty liver caused by lack of exercise -The merits and demerits of the combination with dietary restrictions-

Research Project

Project/Area Number 16K21336
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied health science
Eating habits
Research InstitutionJuntendo University (2018-2021)
Wayo Women's University (2016-2017)

Principal Investigator

Kurosaka Yuka  順天堂大学, スポーツ健康科学部, 助手 (30633002)

Project Period (FY) 2016-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords非アルコール性脂肪肝 / 運動習慣 / 不活動 / 食事療法 / 食事制限 / 脂肪肝 / 栄養不良 / 運動不足 / 身体不活動 / 骨格筋 / 食餌制限 / 肥満 / 坐骨神経切除
Outline of Final Research Achievements

Dietary restriction is one of the effective prevention and improvement methods for non-alcoholic fatty liver, but sometimes dietary restriction does not act effectively. This study focused on the role of exercise in fatty liver prevention, and aimed to determine whether dietary restriction prevents or improves fatty liver as determined by skeletal muscle mass and activity level. In a study in an animal model of inactivity, it was suggested that the elimination of inactivity may have a protective effect on hepatic fat accumulation induced by dietary restriction.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果は、脂肪肝の予防に対しては、単にエネルギー摂取量とエネルギー消費量とのバランスだけが重要なのではなく、運動習慣があるか否か、骨格筋の発達状態が十分であるかが重要な役割を担っている可能性があることを確認した。ヒトにおける適用には、まだ今後の検討が必要であるものの、食事制限のみに頼った体重コントロール方法は、必ずしも肝脂肪蓄積への良い影響が認められるわけではなく、運動不足や骨格筋の発達不良と重なることで、悪化を導く可能性が考えられる。

Report

(7 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2022 2021 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Protective Effects of Voluntary Exercise on Hepatic Fat Accumulation Induced by Dietary Restriction in Zucker Fatty Rats2021

    • Author(s)
      Kurosaka Yuka、Machida Shuichi、Shiroya Yoko、Yamauchi Hideki、Minato Kumiko
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 4 Pages: 2014-2014

    • DOI

      10.3390/ijms22042014

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective effects of dietary restriction and physical exercise on intrahepatic fat accumulation2018

    • Author(s)
      Yuka Kurosaka, Hideki Yamauchi, Shigeru Takemori, Kumiko Minato
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 7 Issue: 1 Pages: 9-14

    • DOI

      10.7600/jpfsm.7.9

    • NAID

      130006315877

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 過食性脂肪肝ラットの食餌制限により低下した肝脂肪酸結合タンパク質発現は運動により改善される2019

    • Author(s)
      黒坂裕香,湊久美子、山内秀樹、町田修一、内藤久士
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 高脂肪食誘導型脂肪肝のリポタンパク質プロファイルと自発的運動の影響2019

    • Author(s)
      黒坂裕香,内藤久士,町田修一,湊久美子
    • Organizer
      第26回日本健康体力栄養学会大会
    • Related Report
      2018 Research-status Report
  • [Book] 部活動指導員ガイドブック[応用編]2022

    • Author(s)
      藤後 悦子、大橋 恵、井梅 由美子
    • Total Pages
      208
    • Publisher
      ミネルヴァ書房
    • ISBN
      9784623092758
    • Related Report
      2021 Annual Research Report

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Published: 2016-04-21   Modified: 2023-01-30  

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