Stereoselective synthesis of spiroacetal with aldehyde-aldose bearing boronic ester
| Project/Area Number |
16K21340
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
Chemical pharmacy
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| Research Institution | Aoyama Gakuin University |
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Principal Investigator |
Sasaki Ikuo 青山学院大学, 理工学部, 助教 (10771040)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ホウ酸エステル / テトラヒドロフラン合成反応 / スピロアセタール / 三フッ化ホウ素ジエチルエーテル錯体 / アルデヒド糖 / テトラヒドロフラン合成 / 天然物合成 / ルイス酸 / 有機化学 / 合成化学 |
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| Outline of Final Research Achievements |
Bioactive natural products bearing spiroacetal structure exist widely in nature, development of novel and efficient synthesis of spiroacetal structure is one of important study in synthetic and medicinal chemistry. Herein, I focus on unique and useful nature of boron atom, development of novel synthesis of spiroacetal ring with aldehyde-aldose having boronic ester was studied. Synthesis of aldehyde-aldose bearing boronic ester was succeeded, aldehyde-aldose decomposed quickly under the annulation reaction conditions. On the other hands, the synthesis of spiroacetal core of Xylapyrroside B1 which showed antitumor activity was achieved.
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Report
(3 results)
Research Products
(1 results)
