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Attempt to noninvasive assessment of retinal function using pupillary response

Research Project

Project/Area Number 16K21346
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Medical engineering assessment
Research InstitutionKitasato University

Principal Investigator

Asakawa Ken  北里大学, 医療衛生学部, 講師 (60582749)

Co-Investigator(Renkei-kenkyūsha) ISHIKAWA Hitoshi  北里大学, 医療衛生学部, 教授 (80265701)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords対光反射 / 網膜電図 / 視細胞 / 網膜神経節細胞 / 網膜 / 瞳孔
Outline of Final Research Achievements

The pupil response to colored-light stimulus may be useful to detect signs and symptoms in diseases of the retina, optic nerve and visual pathways, based on our normative database. In future, we intend to develop a screening device to detect the various neurological abnormalities by evaluating in combination with the electroretinography and the colored-light pupil response.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (30 results)

All 2018 2017 2016

All Journal Article (15 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 14 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Invited: 5 results) Book (3 results)

  • [Journal Article] Evaluation of a Relative Afferent Pupillary Defect using the RAPDx® Device Before and After Treatment in Patients with Optic Nerve Disease2018

    • Author(s)
      Tsukasa Satou, Hitoshi Ishikawa, Toshiaki Goseki, Ken Asakawa
    • Journal Title

      Neuroophthalmology

      Volume: 印刷中 Issue: 3 Pages: 1-4

    • DOI

      10.1080/01658107.2017.1380050

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of astigmatic axis orientation on postural stabilization with stationary equilibrium2017

    • Author(s)
      Kanazawa Masatsugu、Uozato Hiroshi、Asakawa Ken、Kawamorita Takushi
    • Journal Title

      Optical Review

      Volume: 25 Issue: 1 Pages: 27-32

    • DOI

      10.1007/s10043-017-0383-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不同視弱視における対光反射の左右差に関する研究2017

    • Author(s)
      戸塚悟,石川均,後関利明,浅川賢,庄司信行
    • Journal Title

      眼科臨床紀要

      Volume: 10 Pages: 646-650

    • NAID

      40021298868

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Mydriasis-Free Electroretinogram Recorded with Skin Electrodes in Healthy Subjects2017

    • Author(s)
      Asakawa Ken、Amino Kana、Iwase Machiho、Kusayanagi Yuki、Nakamura Akiho、Suzuki Rio、Yuuki Takashi、Ishikawa Hitoshi
    • Journal Title

      Biomed Research International

      Volume: 2017 Pages: 1-7

    • DOI

      10.1155/2017/8539747

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reproducibility and Normative Values of the Parameters of a New Hand-Held Digital Pupillometer2017

    • Author(s)
      Asakawa Ken、Ishikawa Hitoshi
    • Journal Title

      Journal of Clinical & Experimental Ophthalmology

      Volume: 08 Issue: 03 Pages: 1-2

    • DOI

      10.4172/2155-9570.1000654

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 片眼性黄斑低形成における黄斑異常と色光刺激による瞳孔反応2017

    • Author(s)
      浅川賢,石川均,龍井苑子,後関利明,池田哲也,庄司信行
    • Journal Title

      日本眼科学会雑誌

      Volume: 121 Pages: 383-383

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新しい瞳孔・調節検査2017

    • Author(s)
      浅川賢,石川均
    • Journal Title

      日本の眼科

      Volume: 88 Pages: 458-462

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histopathological changes of inner retina, optic disc, and optic nerve in rabbit with advanced retinitis pigmentosa.2016

    • Author(s)
      Asakawa K, Ishikawa H, Uga S, Mashimo K, Kondo M, Terasaki H.
    • Journal Title

      Neuroophthalmology.

      Volume: 40 Issue: 6 Pages: 286-291

    • DOI

      10.1080/01658107.2016.1229339

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of periocular warm compresses with and without menthol stimulation on visual function and autonomic nervous system2016

    • Author(s)
      Yuko Shimada,Natsuki Iimori,Michihito Igaki,Yo Iwata,Ken Asakawa,Hitoshi Ishikawa
    • Journal Title

      自律神経

      Volume: 53 Pages: 173-177

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electroretinography and pupillography in unilateral foveal hypoplasia2016

    • Author(s)
      Asakawa K, Ishikawa H
    • Journal Title

      J Pediatr Ophthalmol Strabismus

      Volume: 53 Issue: 6 Pages: 26-28

    • DOI

      10.3928/01913913-20160509-04

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effects of ripasudil hydrochloride hydrate instillation on pupil dynamics2016

    • Author(s)
      Tsukasa Sato,Hitoshi Ishikawa,Ken Asakawa,Toshiaki Goseki,Kimiya Shimizu
    • Journal Title

      Current Eye Research

      Volume: 1 Issue: 1 Pages: 1-4

    • DOI

      10.3109/02713683.2016.1148740

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of age and sex on values obtained by RAPDx® pupillometer, and determined the standard values for detecting relative afferent pupillary defect2016

    • Author(s)
      Satou T, Goseki T, Asakawa K, Ishikawa H, Shimizu K
    • Journal Title

      Transl. Vis. Sci. Technol

      Volume: 5(2)18 Issue: 2 Pages: 1-5

    • DOI

      10.1167/tvst.5.2.18

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Evaluation of relative afferent pupillary defect using RAPDx device in patients with optic nerve disease2016

    • Author(s)
      Tsukasa Sato,Hitoshi Ishikawa,Ken Asakawa,Toshiaki Goseki, Kimiya Shimizu,Takahiro Niida
    • Journal Title

      Neuro-Ophthalmology

      Volume: 40 Issue: 3 Pages: 120-124

    • DOI

      10.3109/01658107.2016.1169550

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 対光反射解析装置RAPDx2016

    • Author(s)
      佐藤司,後関利明,浅川賢
    • Journal Title

      眼科

      Volume: 58 Pages: 1179-1187

    • Related Report
      2016 Research-status Report
  • [Journal Article] メラノプシン含有網膜神経節細胞2016

    • Author(s)
      浅川賢,石川均
    • Journal Title

      日本の眼科

      Volume: 87 Pages: 1095-1096

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 神経眼科疾患を見逃さないコツと検査の進め方 -いつもの所見、理解すれば神経眼科!-2017

    • Author(s)
      浅川賢
    • Organizer
      第55回日本神経眼科学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 未熟児網膜症の光凝固術前後でのRETeval測定を試みた一例2017

    • Author(s)
      池田哲也,石川均,浅川賢,後関利明,庄司信行
    • Organizer
      第55回日本神経眼科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メラノプシン含有網膜神経節細胞の機能評価と形態観察2017

    • Author(s)
      浅川賢
    • Organizer
      第2回CREAS
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヘッドマウント型視野計による瞳孔視野測定の試み2017

    • Author(s)
      浅川賢,石川均,庄司信行
    • Organizer
      第28回日本緑内障学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 健常成人におけるSpot Vison Screenerの測定精度に関する検討2017

    • Author(s)
      越地理沙子,後関利明,保科美希,浅川賢,龍井苑子,石川均,庄司信行
    • Organizer
      第73回日本弱視斜視学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 視神経疾患におけるRAPDxを用いた治療前後の相対的瞳孔求心路障害の評価2016

    • Author(s)
      佐藤司,後関利明,石川均,浅川賢,新井田孝裕
    • Organizer
      第54回日本神経眼科学会
    • Place of Presentation
      宮崎(宮崎市民プラザ)、宮崎県
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 色光刺激による対光反射の経時変化を追えた乳児の一例2016

    • Author(s)
      戸塚悟,浅川賢,後関利明,石川均
    • Organizer
      第54回日本神経眼科学会
    • Place of Presentation
      宮崎(宮崎市民プラザ)、宮崎県
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 片眼性黄斑低形成における黄斑異常と色光刺激による瞳孔反応2016

    • Author(s)
      浅川賢,石川均,龍井苑子,後関利明,池田哲也
    • Organizer
      第54回日本神経眼科学会
    • Place of Presentation
      宮崎(宮崎市民プラザ)、宮崎県
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 1/fゆらぎを持つ機械乗馬は副交感神経活動を賦活化し血管内皮機能を改善させるか2016

    • Author(s)
      石谷周士,田中伸弥,高下大輔,玉置友夏子,浅川賢,増田卓,横山美佐子
    • Organizer
      第35回関東甲信越ブロック理学療法士学会
    • Place of Presentation
      横浜(パシフィコ横浜)、神奈川県
    • Year and Date
      2016-10-29
    • Related Report
      2016 Research-status Report
  • [Presentation] 視野検査に必要な知識と結果のみかた2016

    • Author(s)
      浅川賢
    • Organizer
      第10回湘西学術講演会・スタッフ講習会
    • Place of Presentation
      本厚木(レンブラントホテル厚木)、神奈川県
    • Year and Date
      2016-10-01
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 瞳孔視野測定の有用性と将来展望2016

    • Author(s)
      浅川賢
    • Organizer
      第27回日本緑内障学会
    • Place of Presentation
      横浜(パシフィコ横浜)、神奈川県
    • Year and Date
      2016-09-18
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ブルーライトの必要性2016

    • Author(s)
      浅川賢
    • Organizer
      下田メディカル講習会
    • Place of Presentation
      下田(下田メディカルセンター)、静岡県
    • Year and Date
      2016-06-24
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] Advances in Medicine and Biology -Recent topics in the Retinal Ganglion Cells-2017

    • Author(s)
      Asakawa Ken,Leon V.Berhardt(Editor)
    • Total Pages
      236
    • Publisher
      Nova Science Publishers Inc.
    • ISBN
      9781536110104
    • Related Report
      2017 Annual Research Report
  • [Book] 今日の眼疾患治療指針2016

    • Author(s)
      浅川賢,石川均
    • Total Pages
      9
    • Publisher
      医学書院
    • Related Report
      2016 Research-status Report
  • [Book] 眼科診療プラクティス-眼科検査ガイド第2版2016

    • Author(s)
      浅川賢,石川均
    • Total Pages
      15
    • Publisher
      文光堂
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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