| Project/Area Number |
16K21349
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
Eating habits
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Research Collaborator |
NOZAKI Tsutomu
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | インスリン抵抗性 / PPARγ / 黒ショウガ / 骨格筋 / 脂質 / ２型糖尿病 / 脂質蓄積 / 2型糖尿病 / NSYマウス / 黒ショウガ抽出物 / 骨格筋脂質 / アディポネクチン / 栄養学 |
|---|
| Outline of Final Research Achievements |
Muscular fat accumulation can lead to the onset of type-2 diabetes mellitus, but fat content is highly accumulated in muscles of endurance athlete. This is well called “athlete paradox”. As a PPARγ agonist to stimulate adiponectin production and its secretion, ethanol extract of Kaempferia parviflora was selected. From the animal studies using a PPARγ agonist and its antagonist, ethanol extract of Kaempferia parviflora showed PPAR agonistic activities and improved glucose tolerance without excess fat accumulation in skeletal muscles. These results can indicate that the anti-type-2 diabetes mellitus effects were caused by not only the activation of PPARγ but also other mechanisms. And, as food factors to produce fat containing muscles, 5, 7-dimethoxyflavones were also one of effective.
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