Project/Area Number |
16K21350
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
General surgery
Digestive surgery
|
Research Institution | Kitasato University |
Principal Investigator |
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 肝修復 / プロスタグランジン / 再潅流 / 再灌流 / プロスタグランディン / 再生医学 / 外科 |
Outline of Final Research Achievements |
Impaired liver repair after liver surgery causes liver dysfunction, which is associated with a increased risk of morbidity and mortality. Here, we show that membranous prostaglandin synthase suppresses liver repair after liver injury in mice. mPGES-1 promotes accumulation of inflammatory macrophages, but not reparative macrophages, leading to delay in liver repair. Mice treated with the mPGES-1 inhibitor displayed increased liver protection and repair.
|