Hydrogen gas inhalation improves survival in rats with lethal hemorrhagic shock.
| Project/Area Number |
16K21357
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
General surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 出血性ショック / 水素ガス / 水素 / 外科 / 救命 |
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| Outline of Final Research Achievements |
We investigated whether hydrogen (H2) gas inhalation would influence the tolerance to hemorrhagic shock (HS) and improve survival.
The survival rate at 6 hours after HS and resuscitation (MAP:30 mmHg, 60 min, normal saline equal to four times the volume of shed blood) was 80% in the H2 gas (1.3%H2, 26%O2) group and 30% in the control gas (26%O2) group (the gas inhalation from the start of HS to 2 hours after resuscitation)(p<0.05). The shed blood volume to induce HS was significantly larger in the H2 group. Despite losing more blood, the increase in serum potassium after HS was suppressed in the H2 group. Fluid resuscitation completely restored blood pressure (BP) in the H2 group, whereas it failed to fully restore BP in the control group. At 2 hours after resuscitation, metabolic acidosis was well compensated in the H2 group, while the control group has uncompensated metabolic acidosis and hyperkalemia.
We demonstrated H2 gas inhalation delays the progression to irreversible shock.
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Report
(3 results)
Research Products
(7 results)
