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Hydrogen gas inhalation improves survival in rats with lethal hemorrhagic shock.

Research Project

Project/Area Number 16K21357
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
General surgery
Research InstitutionKeio University

Principal Investigator

Matsuoka Tadashi  慶應義塾大学, 医学部(信濃町), 助教 (70649938)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords出血性ショック / 水素ガス / 水素 / 外科 / 救命
Outline of Final Research Achievements

We investigated whether hydrogen (H2) gas inhalation would influence the tolerance to hemorrhagic shock (HS) and improve survival.
The survival rate at 6 hours after HS and resuscitation (MAP:30 mmHg, 60 min, normal saline equal to four times the volume of shed blood) was 80% in the H2 gas (1.3%H2, 26%O2) group and 30% in the control gas (26%O2) group (the gas inhalation from the start of HS to 2 hours after resuscitation)(p<0.05). The shed blood volume to induce HS was significantly larger in the H2 group. Despite losing more blood, the increase in serum potassium after HS was suppressed in the H2 group. Fluid resuscitation completely restored blood pressure (BP) in the H2 group, whereas it failed to fully restore BP in the control group. At 2 hours after resuscitation, metabolic acidosis was well compensated in the H2 group, while the control group has uncompensated metabolic acidosis and hyperkalemia.
We demonstrated H2 gas inhalation delays the progression to irreversible shock.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Promising novel therapy with hydrogen gas for emergency and critical care medicine2017

    • Author(s)
      Sano Motoaki、Suzuki Masaru、Homma Koichiro、Hayashida Kei、Tamura Tomoyoshi、Matsuoka Tadashi、Katsumata Yoshinori、Onuki Shuko、Sasaki Junichi
    • Journal Title

      Acute Medicine & Surgery

      Volume: 5 Issue: 2 Pages: 113-118

    • DOI

      10.1002/ams2.320

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 出血性ショックに対する水素ガス吸入療法の可能性2018

    • Author(s)
      松岡 義
    • Organizer
      日本救急医学総会 2018
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット出血性ショックモデルにおける水素ガス吸入の生存率改善効果について2017

    • Author(s)
      松岡 義
    • Organizer
      腹部救急医学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2017-03-02
    • Related Report
      2016 Research-status Report
  • [Presentation] Hydrogen gas inhalation improves survival in rats with lethal hemorrhagic shock.2017

    • Author(s)
      Tadashi Matsuoka
    • Organizer
      European society of cardiology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Early use of Hydrogen gas inhalation improves survival in rats with lethal hemorrhagic shock.2017

    • Author(s)
      Tadashi Matsuoka
    • Organizer
      American Heart Association 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hydrogen Gas Inhalation Improves Survival in Rats With Lethal Hemorrhagic Shock Resuscitated With Saline2016

    • Author(s)
      松岡 義
    • Organizer
      American Heart Association
    • Place of Presentation
      ニューオーリンズ(アメリカ合衆国)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 出血性ショックに対する救急処置用の医薬品組成物2016

    • Inventor(s)
      慶應義塾大学
    • Industrial Property Rights Holder
      慶應義塾大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-07-29
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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