Metabolic hallmark of epithelial-mesenchymal transition in non-small cell lung cancer
| Project/Area Number |
16K21361
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
Pathological medical chemistry
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| Research Institution | Keio University |
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Principal Investigator |
TABATA Sho 慶應義塾大学, 政策・メディア研究科(藤沢), 訪問講師 (30708342)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | がん代謝 / 上皮間葉転換 / EMT / metabolome / メタボローム |
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| Outline of Final Research Achievements |
Epithelial-mesenchymal transition (EMT) is a key event in cancer metastasis that directly contributes to poor prognosis. Here, we found that the loss of amino acids elicited by TGF-β signaling are important for transdifferentiation and consequently contribute to metastasis and anti-cancer drug resistance. These findings suggest that the loss of amino acids induced by TGF-β is critical for EMT in cancer cells, and indicate a potential target for therapeutics.
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| Academic Significance and Societal Importance of the Research Achievements |
これまでのEMT研究では、EMTに関連する遺伝子の転写、翻訳機構、非コードRNAの制御、選択的スプライシングやタンパク質安定性など、様々な分子機構が報告されている。しかしながら、EMT特異的な代謝変化およびその機構については十分な理解がなされていない。今回、EMTにおける網羅的な代謝解析を行い、特異的アミノ酸代謝を見出し、その代謝を制御する代謝遺伝子を同定した。本結果は、がんEMTの理解を深めることができ、がん治療の開発に繋がる可能性がある。
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells2018
Author(s)
Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Toyoda Y, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI.
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Journal Title
Sci Rep.
Volume: 8
Issue: 1
Pages: 6760-6760
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Thymidine Catabolism as a Metabolic Strategy for Cancer Survival2017
Author(s)
Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI
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Journal Title
Cell Rep
Volume: 19
Issue: 7
Pages: 1313-1321
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC2017
Author(s)
Satoh K, Yachida S, Sugimoto M, Oshima M, Nakagawa T, Akamoto S, Tabata S, Saitoh K, Kato K, Sato S, Igarashi K, Aizawa Y, Kajino-Sakamoto R, Kojima Y, Fujishita T, Enomoto A, Hirayama A, Ishikawa T, Taketo MM, Kushida Y, Haba R, Okano K, Tomita M, Suzuki Y, Fukuda S, Aoki M, Soga T.
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Journal Title
Proc Natl Acad Sci U S A
Volume: 114
Issue: 37
DOI
Related Report
Peer Reviewed
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