Exercise and visceral adiposity in relation to diabetes onset and factors associated with visceral adiposity

• Project/Area Number: 16K21379
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science; Epidemiology and preventive medicine
• Research Institution: Teikyo University
• Principal Investigator: Kuwahara Keisuke 帝京大学, 大学院公衆衛生学研究科, 講師 (70635226)
• Research Collaborator: HAYASHI TAKESHI ; NAKAGAWA TOHRU ; YAMAMOTO SHUICHIRO ; HONDA TORU ; MIZOUE TETSUYA
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Keywords: 活動的な通勤手段 / 公共交通機関 / 内臓脂肪 / 運動 / 糖尿病 / 予防 / 生活習慣 / 仕事中の身体活動 / 公共交通機関利用 / アクティブな通勤 / 労働者 / 観察研究 / 身体活動 / コホート研究 / 通勤手段 / 皮下脂肪 / 疾病予防

Outline of Final Research Achievements

Before the development of type 2 diabetes among Japanese, visceral fat gain occurs; the extent of visceral fat gain before the onset of diabetes depends on the individuals' insulin secretory capacity. Although high level of visceral fat may increase diabetes risk, leisure-time exercise may reduce the increased risk associated with high visceral fat. To suppress the increase in the visceral fat among workers, active commuting or public transportation use may be useful, as compared with inactive commuting (e.g., car commuting). In addition to active commuting or public transportation use, being physically active at leisure-time or work may also help suppress the increase in visceral fat.

Academic Significance and Societal Importance of the Research Achievements

内臓脂肪が増えると糖尿病発症リスクは高まるが、運動を行うことでそのリスクを軽減できる可能性が示された。働く世代において内臓脂肪の増加を抑制するには、余暇に運動を行うことや、仕事中に体を動かすことに加えて、マイカー通勤をやめて徒歩や自転車といったアクティブな通勤手段、あるいは電車・バスなどの公共交通機関利用といったより身体的にアクティブな通勤手段を取り入れ、継続することも役立つことが本研究で明らかになった。化石燃料の燃焼を主とする大気汚染が世界的な健康課題となっており、アクティブな通勤手段や公共交通機関を利用した通勤は環境負荷の面から見ても好ましいため、その活用と普及が望まれる。

Research Products

• [Journal Article] Patterns of changes in overtime working hours over 3 years and the risk for progression to type 2 diabetes in adults with pre-diabetes (2019)
  • Author(s): Kuwahara K, Miyamoto T, Yamamoto S, Honda T, Nakagawa T, Mizoue T; Japan Epidemiology Collaboration on Occupational Health Study Group
  • Journal Title: Preventive Medicine Volume: 121 Pages: 18-23
  • DOI: 10.1016/j.ypmed.2019.02.002
  • Peer Reviewed
• [Journal Article] Sleep Duration Modifies the Association of Overtime Work With Risk of Developing Type 2 Diabetes: Japan Epidemiology Collaboration on Occupational Health Study (2018)
  • Author(s): Kuwahara K, Imai T, Miyamoto T, Kochi T, Eguchi M, Nishihara A, Nakagawa T, Yamamoto S, Honda T, Kabe I, Mizoue T, Dohi S
  • Journal Title: Journal of Epidemiology Volume: 28 Issue: 7 Pages: 336-340
  • DOI: 10.2188/jea.JE20170024
  • NAID: 130007394052
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2018-07-05
  • Peer Reviewed / Open Access
• [Journal Article] Intensity of Leisure-Time Exercise and Risk of Depressive Symptoms Among Japanese Workers: A Cohort Study (2018)
  • Author(s): Kuwahara K, Honda T, Nakagawa T, Yamamoto S, Hayashi T, Mizoue T
  • Journal Title: Journal of Epidemiology Volume: 28 Issue: 2 Pages: 94-98
  • DOI: 10.2188/jea.JE20170009
  • NAID: 130006337733
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access
• [Journal Article] Intensity of leisure-time exercise and risk of depressive symptoms among Japanese workers: a cohort study (2018)
  • Author(s): Kuwahara K, Honda T, Nakagawa T, Yamamoto S, Hayashi T, Mizoue T.
  • Journal Title: Journal of Epidemiology Volume: 28
  • NAID: 130006337733
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Body mass index trajectory patterns and changes in visceral fat and glucose metabolism before the onset of type 2 diabetes (2017)
  • Author(s): Kuwahara K, Honda T, Nakagawa T, Yamamoto S, Hayashi T, Mizoue T.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 43521-43521
  • DOI: 10.1038/srep43521
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 通勤手段の変化と内臓脂肪の変化-5年間の観察研究の結果から- (2019)
  • Author(s): 桑原恵介, 中川徹, 山本修一郎, 本多融, 林剛司, 溝上哲也
  • Organizer: 第29回日本疫学会学術総会
• [Presentation] 通勤手段の変化と体重の変化―5年間の観察研究の結果から― (2018)
  • Author(s): 桑原恵介, 中川徹, 山本修一郎, 本多融, 林剛司, 溝上哲也
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] Association of lifestyles, occupational factors, and marital status with 3-year changes in visceral fat accumulation among adults in Japan (2017)
  • Author(s): Kuwahara K, Nakagawa T, Honda T, Yamamoto S, Hayashi T, Mizoue T
  • Organizer: The 21st International Epidemiological Association, World Congress of Epidemiology 2017
• [Presentation] 代謝的に健康な内臓脂肪型肥満および運動の組み合わせと2型糖尿病発症との関連に関するコホート研究 (2017)
  • Author(s): 桑原恵介, 本多融, 中川徹, 山本修一郎, 林剛司, 溝上哲也
  • Organizer: 第27回日本疫学会学術総会
  • Place of Presentation: ベルクラシック甲府（山梨県甲府市）