| Project/Area Number |
16K21386
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genome biology
Genetics/Chromosome dynamics
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| Research Institution | Tokai University |
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Principal Investigator |
NAKAGAWA So 東海大学, 医学部, 助教 (70510014)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | レトロウイルス / レトロトランスポゾン / 比較ゲノム / 分子進化 / データベース / 機能ゲノム / 内在性ウイルス様配列 / トランスポゾン / 内在性レトロウイルス / ゲノム進化 / 新規機能性配列探索 / バイオインフォマティクス |
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| Outline of Final Research Achievements |
The aim of this research project is to clarify various new functions gained by endogenous viral elements (EVEs) in mammalian genomes and their genome evolution. I have developed an annotation database called gEVE for possible protein-coding sequences derived from EVEs. In this study, we have identified various new functional sequences derived from EVE using NGS data analyzed with this database. For example, we discovered a novel structural protein Gag-like retroviral gene expressed in bovine placenta by collaborative research. We also identified non-coding regions derived from EVE and predicted that it might have acquired the function such as promoters.
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