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Developmental mechanism of muscle-tendon-bone complex in the craniofacial region.

Research Project

Project/Area Number 16K21390
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Morphological basic dentistry
Research InstitutionTokyo Dental College

Principal Investigator

Yamamoto Masahito  東京歯科大学, 歯学部, 講師 (90733767)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords筋-腱-骨複合体 / 頭部 / マウス / 運動器 / 腱骨格系前駆細胞 / 筋原基 / Sox9 / 顎顔面領域 / 発生 / 発生学 / 筋-腱接合部 / 腱-筋接合部
Outline of Final Research Achievements

This study was performed to investigate how the palatine aponeurosis, medial pterygoid process (MPP) of the sphenoid bone, and tensor veli palatini (TVP) muscle form the pulley: muscle-tendon-bone complex.At E14 and 14.5, ALP showed a reaction throughout the MPP. The col II-positive area expanded until E16.5, but it was markedly reduced at E17. The TVP initially contacted with the palatine aponeurosis at E16.5. The major axis and width of the MPP and the number of TRAP-positive osteoclasts were significantly increased as the TVP and palatine aponeurosis joined.Therefore, in addition to the tissue units: muscle, tendon, and bone, the interaction in organogenesis promotes rapid growth of the pulley: muscle-tendon-bone complex.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] Developmental characteristics of secondary cartilage in the mandibular condyle and sphenoid bone in mice.2018

    • Author(s)
      Hirouchi H, Kitamura K, Yamamoto M, Odaka K, Matsunaga S, Sakiyama K, Abe S.
    • Journal Title

      Arch Oral Biol.

      Volume: 89 Pages: 84-92

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental mechanism of muscle-tendon-bone complex in the fetal soft palate.2017

    • Author(s)
      Nara M, Kitamura K, Yamamoto M, Nagakura R, Mitomo K, Matsunaga S, Abe S.
    • Journal Title

      Arch Oral Biol.

      Volume: 82 Pages: 71-78

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphology and relationships of ultimobranchial body with pharyngeal pouches2017

    • Author(s)
      Masahito Yamamoto, Yohei Honkura, Jose Francisco Rodriguez Vazquez, Gen Murakami, Yukio Katori, Shin-ichi Abe
    • Journal Title

      European Journal of Anatomy

      Volume: 21(2)

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 顎顔面領域における''筋-腱-骨複合体''の発達メカニズム2018

    • Author(s)
      山本 将仁
    • Organizer
      日本解剖学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胎生期マウス外側翼突筋停止部における付着機序の解明2017

    • Author(s)
      永倉遼太郎、廣内英智、奈良 倫之、山本 将仁、松永 智、阿部 伸一
    • Organizer
      第122回日本解剖学会総会・学術大会集会
    • Place of Presentation
      長崎市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] ''顎関節の筋・腱・骨機能的複合体''発生過程におけるSox9陽性前駆細胞の担う役割2017

    • Author(s)
      山本 将仁
    • Organizer
      歯科基礎医学会
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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